PROTACs are effective in addressing the platelet toxicity associated with BCL-X(L) inhibitors

BCL-X(L) is an anti-apoptotic protein that plays an important role in tumorigenesis, metastasis, and intrinsic or therapy-induced cancer drug resistance. More recently, BCL-X(L) has also been identified as a key survival factor in senescent cells. Accumulation of senescent cells has been indicated a...

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Detalles Bibliográficos
Autores principales: Zhang, Peiyi, Zhang, Xuan, Liu, Xingui, Khan, Sajid, Zhou, Daohong, Zheng, Guangrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293695/
https://www.ncbi.nlm.nih.gov/pubmed/34296214
http://dx.doi.org/10.37349/etat.2020.00017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293695/
https://www.ncbi.nlm.nih.gov/pubmed/34296214
http://dx.doi.org/10.37349/etat.2020.00017

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