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PROTACs are effective in addressing the platelet toxicity associated with BCL-X(L) inhibitors
BCL-X(L) is an anti-apoptotic protein that plays an important role in tumorigenesis, metastasis, and intrinsic or therapy-induced cancer drug resistance. More recently, BCL-X(L) has also been identified as a key survival factor in senescent cells. Accumulation of senescent cells has been indicated a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Open Exploration
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293695/ https://www.ncbi.nlm.nih.gov/pubmed/34296214 http://dx.doi.org/10.37349/etat.2020.00017 |