Discovery of Novel HCN4 Blockers with Unique Blocking Kinetics and Binding Properties

The hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) channel underlies the pacemaker currents, called “If,” in sinoatrial nodes (SANs), which regulate heart rhythm. Some HCN4 blockers such as ivabradine have been extensively studied for treating various heart diseases. Studies have shown...

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Detalles Bibliográficos
Autores principales: Nakashima, Kosuke, Nakao, Kenji, Matsui, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293762/
https://www.ncbi.nlm.nih.gov/pubmed/34041946
http://dx.doi.org/10.1177/24725552211013824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293762/
https://www.ncbi.nlm.nih.gov/pubmed/34041946
http://dx.doi.org/10.1177/24725552211013824

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