Development of a structure-based computational simulation to optimize the blocking efficacy of pro-antibodies

The on-target toxicity of monoclonal antibodies (Abs) is mainly due to the fact that Abs cannot distinguish target antigens (Ags) expressed in disease regions from those in normal tissues during systemic administration. In order to overcome this issue, we “copied” an autologous Ab hinge as an “Ab lo...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Bo-Cheng, Lu, Yun-Chi, Liao, Jun-Min, Liu, Hui-Ju, Hong, Shih-Ting, Hsieh, Yuan-Chin, Chuang, Chih-Hung, Chen, Huei-Jen, Liao, Tzu-Yi, Ho, Kai-Wen, Wang, Yeng-Tseng, Cheng, Tian-Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293997/
https://www.ncbi.nlm.nih.gov/pubmed/34349949
http://dx.doi.org/10.1039/d1sc01748a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293997/
https://www.ncbi.nlm.nih.gov/pubmed/34349949
http://dx.doi.org/10.1039/d1sc01748a

Ejemplares similares