Cargando…

Development of a structure-based computational simulation to optimize the blocking efficacy of pro-antibodies

The on-target toxicity of monoclonal antibodies (Abs) is mainly due to the fact that Abs cannot distinguish target antigens (Ags) expressed in disease regions from those in normal tissues during systemic administration. In order to overcome this issue, we “copied” an autologous Ab hinge as an “Ab lo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Bo-Cheng, Lu, Yun-Chi, Liao, Jun-Min, Liu, Hui-Ju, Hong, Shih-Ting, Hsieh, Yuan-Chin, Chuang, Chih-Hung, Chen, Huei-Jen, Liao, Tzu-Yi, Ho, Kai-Wen, Wang, Yeng-Tseng, Cheng, Tian-Lu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293997/ https://www.ncbi.nlm.nih.gov/pubmed/34349949 http://dx.doi.org/10.1039/d1sc01748a

Ejemplares similares

Correction: Development of a structure-based computational simulation to optimize the blocking efficacy of pro-antibodies
por: Huang, Bo-Cheng, et al.
Publicado: (2021)

Selective antibody activation through protease-activated pro-antibodies that mask binding sites with inhibitory domains
por: Chen, I-Ju, et al.
Publicado: (2017)

Selective activation of pro-anti-IL-1β antibody enhances specificity for autoinflammatory disorder therapy
por: Lin, Wen-Wei, et al.
Publicado: (2021)

A molecular dynamics simulation study decodes the Zika virus NS5 methyltransferase bound to SAH and RNA analogue
por: Chuang, Chih-Hung, et al.
Publicado: (2018)

Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy
por: Lu, Yun-Chi, et al.
Publicado: (2019)

A Secondary Antibody-Detecting Molecular Weight Marker with Mouse and Rabbit IgG Fc Linear Epitopes for Western Blot Analysis
por: Lin, Wen-Wei, et al.
Publicado: (2016)

Humanized bispecific antibody (mPEG × HER2) rapidly confers PEGylated nanoparticles tumor specificity for multimodality imaging in breast cancer
por: Cheng, Yi-An, et al.
Publicado: (2020)

Anti-TNF Alpha Antibody Humira with pH-dependent Binding Characteristics: A constant-pH Molecular Dynamics, Gaussian Accelerated Molecular Dynamics, and In Vitro Study
por: Hong, Shih-Ting, et al.
Publicado: (2021)

Ab locks for improving the selectivity and safety of antibody drugs
por: Lin, Wen-Wei, et al.
Publicado: (2020)

A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodies
por: Hsieh, Yuan-Chin, et al.
Publicado: (2022)

Functional Production of a Soluble and Secreted Single-Chain Antibody by a Bacterial Secretion System
por: Cheng, Chiu-Min, et al.
Publicado: (2014)

Governance on the Drug Supply Chain via Gcoin Blockchain
por: Tseng, Jen-Hung, et al.
Publicado: (2018)

Cyclic Peptide Inhibitors of the Tsg101 UEV Protein Interactions Refined through Global Docking and Gaussian Accelerated Molecular Dynamics Simulations
por: Lin, Wen-Wei, et al.
Publicado: (2020)

The Prognosis of Blunt Bowel and Mesenteric Injury—The Pitfall in the Contemporary Image Survey
por: Liao, Chien-Hung, et al.
Publicado: (2019)

Differential expression of CD44 and CD24 markers discriminates the epitheliod from the fibroblastoid subset in a sarcomatoid renal carcinoma cell line: evidence suggesting the existence of cancer stem cells in both subsets as studied with sorted cells
por: Hsieh, Chin-Hsuan, et al.
Publicado: (2017)

Double attack strategy for leukemia using a pre-targeting bispecific antibody (CD20 Ab-mPEG scFv) and actively attracting PEGylated liposomal doxorubicin to enhance anti-tumor activity
por: Ho, Kai-Wen, et al.
Publicado: (2021)

High-Throughput Sorting of the Highest Producing Cell via a Transiently Protein-Anchored System
por: Chuang, Kuo-Hsiang, et al.
Publicado: (2014)

Using anti-poly(ethylene glycol) bioparticles for the quantitation of PEGylated nanoparticles
por: Hsieh, Yuan-Chin, et al.
Publicado: (2016)

MiR-424/TGIF2-Mediated Pro-Fibrogenic Responses in Oral Submucous Fibrosis
por: Chou, Ming-Yung, et al.
Publicado: (2023)

A Molecular Dynamics Simulation of the Human Lysozyme – Camelid VHH HL6 Antibody System
por: Su, Zhi-Yuan, et al.
Publicado: (2009)

Epidermal growth factor receptor intron-1 CA repeat polymorphism on protein expression and clinical outcome in Taiwanese oral squamous cell carcinoma
por: Huang, Shiang-Fu, et al.
Publicado: (2017)

Monoclonal enolase-1 blocking antibody ameliorates pulmonary inflammation and fibrosis
por: Huang, Wei-Ching, et al.
Publicado: (2023)

Comparison of associated features and drug treatment between co-occurring unipolar and bipolar disorders in depressed eating disorder patients
por: Tseng, Mei-Chih Meg, et al.
Publicado: (2017)

How much could a low COVID-19 pandemic change the injury trends? A single-institute, retrospective cohort study
por: Kuo, Ling-Wei, et al.
Publicado: (2021)

Enhancement of tumor tropism of mPEGylated nanoparticles by anti-mPEG bispecific antibody for ovarian cancer therapy
por: Lin, Wen-Wei, et al.
Publicado: (2021)

Incidence and outcomes of encapsulating peritoneal sclerosis (EPS) and factors associated with severe EPS
por: Tseng, Chin-Chung, et al.
Publicado: (2018)

The Microbiological Characteristics of Carbapenem-Resistant Enterobacteriaceae Carrying the mcr-1 Gene
por: Chen, Chih-Wei, et al.
Publicado: (2019)

Acrolein: blocking antibody formation: pro tumor, anti-allergy
por: Roth-Walter, Franziska, et al.
Publicado: (2014)

MicroRNA-29a Exhibited Pro-Angiogenic and Anti-Fibrotic Features to Intensify Human Umbilical Cord Mesenchymal Stem Cells—Renovated Perfusion Recovery and Preventing against Fibrosis from Skeletal Muscle Ischemic Injury
por: Su, Wen-Hong, et al.
Publicado: (2019)

Steap4 attenuates high glucose and S100B-induced effects in mesangial cells
por: Chuang, Chao-Tang, et al.
Publicado: (2015)

A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway
por: Lin, Hung-Jen, et al.
Publicado: (2011)

Clinical Implications of FADD Gene Amplification and Protein Overexpression in Taiwanese Oral Cavity Squamous Cell Carcinomas
por: Chien, Huei-Tzu, et al.
Publicado: (2016)

EGFR copy number alterations in primary tumors, metastatic lymph nodes, and recurrent and multiple primary tumors in oral cavity squamous cell carcinoma
por: Huang, Shiang-Fu, et al.
Publicado: (2017)

RhoA/Rho-Kinase and Nitric Oxide in Vascular Reactivity in Rats with Endotoxaemia
por: Liao, Mei-Hui, et al.
Publicado: (2013)

Angiotensin-(1–7) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats
por: Tsai, Hsin-Jung, et al.
Publicado: (2021)

The Influence of Type 2 Diabetes and Glucose-Lowering Therapies on Cancer Risk in the Taiwanese
por: Hsieh, Ming-Chia, et al.
Publicado: (2012)

Patient-oriented simulation based on Monte Carlo algorithm by using MRI data
por: Chuang, Ching-Cheng, et al.
Publicado: (2012)

The association of long-term blood pressure variability with hemodialysis access thrombosis
por: Hsieh, Mu-Yang, et al.
Publicado: (2022)

Intramuscular electroporation with the pro-opiomelanocortin gene in rat adjuvant arthritis
por: Chuang, I-Chuan, et al.
Publicado: (2004)

Risk of Hepatitis B Virus (HBV) Reactivation in HBsAg-Negative, Anti-HBc-Negative Patients Receiving Rituximab for Autoimmune Diseases in HBV Endemic Areas
por: Lan, Ting-Yuan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_1t84qfiruqkgbgrb3cpb8eqvpe