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Molecular basis of anticoagulant and anticomplement activity of the tick salivary protein Salp14 and its homologs
During feeding, a tick's mouthpart penetrates the host's skin and damages tissues and small blood vessels, triggering the extrinsic coagulation and lectin complement pathways. To elude these defense mechanisms, ticks secrete multiple anticoagulant proteins and complement system inhibitors...
Autores principales: | Denisov, Stepan S., Ippel, Johannes H., Castoldi, Elisabetta, Mans, Ben J., Hackeng, Tilman M., Dijkgraaf, Ingrid |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294578/ https://www.ncbi.nlm.nih.gov/pubmed/34118237 http://dx.doi.org/10.1016/j.jbc.2021.100865 |
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