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Roles of constitutive and signal-dependent protein phosphatase 2A docking motifs in burst attenuation of the cyclic AMP response element-binding protein

The cAMP response element-binding protein (CREB) is an important regulator of cell growth, metabolism, and synaptic plasticity. CREB is activated through phosphorylation of an evolutionarily conserved Ser residue (S133) within its intrinsically disordered kinase-inducible domain (KID). Phosphorylati...

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Detalles Bibliográficos
Autores principales: Kim, Sang Hwa, Wu, Cheng-Guo, Jia, Weiyan, Xing, Yongna, Tibbetts, Randal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294589/
https://www.ncbi.nlm.nih.gov/pubmed/34171357
http://dx.doi.org/10.1016/j.jbc.2021.100908