Intranasal plus subcutaneous prime vaccination with a dual antigen COVID-19 vaccine elicits T-cell and antibody responses in mice

We have developed a COVID-19 vaccine, hAd5 S-Fusion + N-ETSD, that expresses SARS-CoV-2 spike (S) and nucleocapsid (N) proteins with modifications to increase immune responses delivered using a human adenovirus serotype 5 (hAd5) platform. Here, we demonstrate subcutaneous (SC) prime and SC boost vac...

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Detalles Bibliográficos
Autores principales: Rice, Adrian, Verma, Mohit, Shin, Annie, Zakin, Lise, Sieling, Peter, Tanaka, Shiho, Balint, Joseph, Dinkins, Kyle, Adisetiyo, Helty, Morimoto, Brett, Higashide, Wendy, Anders Olson, C., Mody, Shivani, Spilman, Patricia, Gabitzsch, Elizabeth, Safrit, Jeffrey T., Rabizadeh, Shahrooz, Niazi, Kayvan, Soon-Shiong, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295250/
https://www.ncbi.nlm.nih.gov/pubmed/34290317
http://dx.doi.org/10.1038/s41598-021-94364-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295250/
https://www.ncbi.nlm.nih.gov/pubmed/34290317
http://dx.doi.org/10.1038/s41598-021-94364-5

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