Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer

BRD4, a Bromodomain and Extraterminal (BET) protein family member, is a promising anti-cancer drug target. However, resistance to BET inhibitors targeting BRD4 is common in solid tumors. Here, we show that cancer-associated fibroblast (CAF)-activated stromal signaling, interleukin-6/8-JAK2, induces...

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Detalles Bibliográficos
Autores principales: Wang, Wenyu, Tang, Yen-An, Xiao, Qian, Lee, Wee Chyan, Cheng, Bing, Niu, Zhitong, Oguz, Gokce, Feng, Min, Lee, Puay Leng, Li, Baojie, Yang, Zi-huan, Chen, Yu-feng, Lan, Ping, Wu, Xiao-Jian, Yu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295257/
https://www.ncbi.nlm.nih.gov/pubmed/34290255
http://dx.doi.org/10.1038/s41467-021-24687-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295257/
https://www.ncbi.nlm.nih.gov/pubmed/34290255
http://dx.doi.org/10.1038/s41467-021-24687-4

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