Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC

Pyruvate kinase M2 as a key rate-limiting enzyme in glycolysis, it plays a critical role in metabolic reprogramming and carcinogenesis. However, whether PKM2 can promote immunosuppressive microenvironment formation remains unknown in head and neck squamous cell carcinoma (HNSCC). PKM2 expression was...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Hanyue, Xu, Qiaoshi, Li, Jiayi, Li, Mingyu, Zhang, Zhiyuan, Ma, Hailong, Yang, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295286/
https://www.ncbi.nlm.nih.gov/pubmed/34290225
http://dx.doi.org/10.1038/s41419-021-03990-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295286/
https://www.ncbi.nlm.nih.gov/pubmed/34290225
http://dx.doi.org/10.1038/s41419-021-03990-4

Ejemplares similares