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Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC

Pyruvate kinase M2 as a key rate-limiting enzyme in glycolysis, it plays a critical role in metabolic reprogramming and carcinogenesis. However, whether PKM2 can promote immunosuppressive microenvironment formation remains unknown in head and neck squamous cell carcinoma (HNSCC). PKM2 expression was...

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Detalles Bibliográficos
Autores principales:	Chang, Hanyue, Xu, Qiaoshi, Li, Jiayi, Li, Mingyu, Zhang, Zhiyuan, Ma, Hailong, Yang, Xi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295286/ https://www.ncbi.nlm.nih.gov/pubmed/34290225 http://dx.doi.org/10.1038/s41419-021-03990-4

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