Neonatal thyroxine activation modifies epigenetic programming of the liver

The type 2 deiodinase (D2) in the neonatal liver accelerates local thyroid hormone triiodothyronine (T3) production and expression of T3-responsive genes. Here we show that this surge in T3 permanently modifies hepatic gene expression. Liver-specific Dio2 inactivation (Alb-D2KO) transiently increase...

Descripción completa

Detalles Bibliográficos
Autores principales: Fonseca, Tatiana L., Garcia, Tzintzuni, Fernandes, Gustavo W., Nair, T. Murlidharan, Bianco, Antonio C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295303/
https://www.ncbi.nlm.nih.gov/pubmed/34290257
http://dx.doi.org/10.1038/s41467-021-24748-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295303/
https://www.ncbi.nlm.nih.gov/pubmed/34290257
http://dx.doi.org/10.1038/s41467-021-24748-8

Ejemplares similares