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Neonatal thyroxine activation modifies epigenetic programming of the liver

The type 2 deiodinase (D2) in the neonatal liver accelerates local thyroid hormone triiodothyronine (T3) production and expression of T3-responsive genes. Here we show that this surge in T3 permanently modifies hepatic gene expression. Liver-specific Dio2 inactivation (Alb-D2KO) transiently increase...

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Detalles Bibliográficos
Autores principales:	Fonseca, Tatiana L., Garcia, Tzintzuni, Fernandes, Gustavo W., Nair, T. Murlidharan, Bianco, Antonio C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295303/ https://www.ncbi.nlm.nih.gov/pubmed/34290257 http://dx.doi.org/10.1038/s41467-021-24748-8

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