Cargando…

Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors

Prostate cancer cells are characterized by a remarkably low proliferative rate and the production of high levels of prostate-specific proteases. Protein-based toxins are attractive candidates for prostate cancer therapy because they kill cells via proliferation-independent mechanisms. However, the n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rogers, O. C., Rosen, D. M., Antony, L., Harper, H. M., Das, D., Yang, X., Minn, I., Mease, R. C., Pomper, M. G., Denmeade, S. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295317/ https://www.ncbi.nlm.nih.gov/pubmed/34290365 http://dx.doi.org/10.1038/s41598-021-94534-5

Ejemplares similares

Heterobivalent Agents Targeting PSMA and Integrin-α(v)β(3)
por: Shallal, Hassan M., et al.
Publicado: (2014)

A Series of PSMA-Targeted Near-Infrared Fluorescent Imaging Agents
por: Chen, Ying, et al.
Publicado: (2022)

A Modular Strategy to Prepare Multivalent Inhibitors of Prostate-Specific Membrane Antigen (PSMA)
por: Banerjee, Sangeeta Ray, et al.
Publicado: (2011)

PSA-selective activation of cytotoxic human serine proteases within the tumor microenvironment as a therapeutic strategy to target prostate cancer
por: Rogers, Oliver C., et al.
Publicado: (2018)

GCP III is not the “off-target” for urea-based PSMA ligands
por: Lee, Zhenghong, et al.
Publicado: (2023)

Prostate-specific membrane antigen (PSMA)-targeted photodynamic therapy enhances the delivery of PSMA-targeted magnetic nanoparticles to PSMA-expressing prostate tumors
por: Ngen, Ethel J., et al.
Publicado: (2021)

A prostate-specific membrane antigen (PSMA)-targeted prodrug with a favorable in vivo toxicity profile
por: Boinapally, Srikanth, et al.
Publicado: (2021)

Imaging CAR T cell therapy with PSMA-targeted positron emission tomography
por: Minn, Il, et al.
Publicado: (2019)

Synthesis and in vitro and in vivo evaluation of urea-based PSMA inhibitors with increased lipophilicity
por: Wirtz, Martina, et al.
Publicado: (2018)

A red-shifted fluorescent substrate for aldehyde dehydrogenase
por: Minn, Il, et al.
Publicado: (2014)

Lys-urea-Aad, Lys-urea-Cmc and Lys-urea-Cms as potential pharmacophores for the design of PSMA-targeted radioligands to reduce off-target uptake in kidneys and salivary glands
por: Kuo, Hsiou-Ting, et al.
Publicado: (2023)

Second-generation aptamer-conjugated PSMA-targeted delivery system for prostate cancer therapy
por: Wu, Xin, et al.
Publicado: (2011)

Preclinical Evaluation of a New Series of Albumin-Binding (177)Lu-Labeled PSMA-Based Low-Molecular-Weight Radiotherapeutics
por: Boinapally, Srikanth, et al.
Publicado: (2023)

PSMA as a target for radiolabelled small molecules
por: Eder, Matthias, et al.
Publicado: (2013)

Optimized (68)Ga-Labeled Urea-Based PSMA-Targeted PET Tracers for Prostate Cancer
por: Wu, Yitian, et al.
Publicado: (2022)

Prostate-specific membrane antigen (PSMA) imaging: the past is prologue and the future is scintillating
por: Rowe, Steven P., et al.
Publicado: (2020)

Cytotoxicity Effects of Different Surfactant Molecules Conjugated to Carbon Nanotubes on Human Astrocytoma Cells
por: Dong, Lifeng, et al.
Publicado: (2009)

Deep learning and radiomics framework for PSMA-RADS classification of prostate cancer on PSMA PET
por: Leung, Kevin H., et al.
Publicado: (2022)

Synthesis and Evaluation of ePSMA-DM1: A New Theranostic Small-Molecule Drug Conjugate (T-SMDC) for Prostate Cancer
por: Murce, Erika, et al.
Publicado: (2023)

Multiparametric dynamic whole-body PSMA PET/CT using [(68)Ga]Ga-PSMA-11 and [(18)F]PSMA-1007
por: Dias, André H., et al.
Publicado: (2023)

Fluorine-18 Labeled Urea-Based Ligands Targeting Prostate-Specific Membrane Antigen (PSMA) with Increased Tumor and Decreased Renal Uptake
por: Basuli, Falguni, et al.
Publicado: (2022)

Engineered Fragments of the PSMA-Specific 5D3 Antibody and Their Functional Characterization
por: Novakova, Zora, et al.
Publicado: (2020)

A Glucose-Triptolide Conjugate Selectively Targets Cancer Cells under Hypoxia
por: Datan, Emmanuel, et al.
Publicado: (2020)

Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours
por: Mahalingam, D, et al.
Publicado: (2016)

Effect of Point-Spread Function Reconstruction for Indeterminate PSMA-RADS-3A Lesions on PSMA-Targeted PET Imaging of Men with Prostate Cancer
por: Khatri, Wajahat, et al.
Publicado: (2021)

Electronic Conductance and Thermopower of Cross-Conjugated and Skipped-Conjugated Molecules in Single-Molecule Junctions
por: Salthouse, Rebecca J., et al.
Publicado: (2023)

All that Glitters on PSMA is Not a Lesion: An Unusual Artifact on PSMA PET/CT
por: Dev, Indraja D., et al.
Publicado: (2021)

PSMA-targeted [(18)F]DCFPyL PET/CT-avid lesions in a patient with prostate cancer: Clinical decision-making informed by the PSMA-RADS interpretive framework
por: Reyes, Diane K., et al.
Publicado: (2019)

PSMA-Oriented Target Delivery of Novel Anticancer Prodrugs: Design, Synthesis, and Biological Evaluations of Oligopeptide-Camptothecin Conjugates
por: Xu, Bing, et al.
Publicado: (2018)

Design, Synthesis, Computational, and Preclinical Evaluation of (nat)Ti/(45)Ti-Labeled Urea-Based Glutamate PSMA Ligand
por: Søborg Pedersen, Kristina, et al.
Publicado: (2020)

Antihormone treatment differentially regulates PSA secretion, PSMA expression and (68)Ga–PSMA uptake in LNCaP cells
por: Mathy, C. S., et al.
Publicado: (2021)

Urea induces intercellular adhesion molecule-1 expression
por: El-Gamal, Dalia, et al.
Publicado: (2011)

Direct Observation of the Orientation of Urea Molecules at Charged Interfaces
por: Moll, Carolyn J., et al.
Publicado: (2021)

Potentiometric Urea Biosensor Based on an Immobilised Fullerene-Urease Bio-Conjugate
por: Saeedfar, Kasra, et al.
Publicado: (2013)

Pitfalls in PSMA imaging: [(18)F]rhPSMA-7-PET/CT reveals presence of chrondrosarcoma
por: Feuerecker, B., et al.
Publicado: (2021)

PSMA Ligand Conjugated PCL-PEG Polymeric Micelles Targeted to Prostate Cancer Cells
por: Jin, Jian, et al.
Publicado: (2014)

Synthesis and preclinical evaluation of novel (18)F-labeled Glu-urea-Glu-based PSMA inhibitors for prostate cancer imaging: a comparison with (18)F-DCFPyl and (18)F-PSMA-1007
por: Robu, Stephanie, et al.
Publicado: (2018)

Synthesis of an Al(18)F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand in an automated synthesis platform
por: Giglio, Javier, et al.
Publicado: (2018)

Glu-Urea-Lys Scaffold Functionalized Superparamagnetic Iron Oxide Nanoparticles Targeting PSMA for In Vivo Molecular MRI of Prostate Cancer
por: Zhou, Wei, et al.
Publicado: (2022)

Proto‐Urea‐RNA (Wöhler RNA) Containing Unusually Stable Urea Nucleosides
por: Okamura, Hidenori, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_if2kcl3fjfap6fuhucgd3nvmb7