Inhibition of the canonical Wnt signaling pathway by a β-catenin/CBP inhibitor prevents heart failure by ameliorating cardiac hypertrophy and fibrosis

In heart failure (HF) caused by hypertension, the myocyte size increases, and the cardiac wall thickens. A low-molecular-weight compound called ICG001 impedes β-catenin-mediated gene transcription, thereby protecting both the heart and kidney. However, the HF-preventive mechanisms of ICG001 remain u...

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Detalles Bibliográficos
Autores principales: Methatham, Thanachai, Tomida, Shota, Kimura, Natsuka, Imai, Yasushi, Aizawa, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295328/
https://www.ncbi.nlm.nih.gov/pubmed/34290289
http://dx.doi.org/10.1038/s41598-021-94169-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295328/
https://www.ncbi.nlm.nih.gov/pubmed/34290289
http://dx.doi.org/10.1038/s41598-021-94169-6

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