Rapid in vitro quantification of TDP-43 and FUS mislocalisation for screening of gene variants implicated in frontotemporal dementia and amyotrophic lateral sclerosis

Identified genetic mutations cause 20% of frontotemporal dementia (FTD) and 5-10% of amyotrophic lateral sclerosis (ALS) cases: however, for the remainder of patients the origin of disease is uncertain. The overlap in genetic, clinical and pathological presentation of FTD and ALS suggests these two...

Descripción completa

Detalles Bibliográficos
Autores principales: Oyston, Lisa J., Ubiparipovic, Stephanie, Fitzpatrick, Lauren, Hallupp, Marianne, Boccanfuso, Lauren M., Kwok, John B., Dobson-Stone, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295343/
https://www.ncbi.nlm.nih.gov/pubmed/34290285
http://dx.doi.org/10.1038/s41598-021-94225-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295343/
https://www.ncbi.nlm.nih.gov/pubmed/34290285
http://dx.doi.org/10.1038/s41598-021-94225-1

Ejemplares similares