Deubiquitinating enzyme USP30 negatively regulates mitophagy and accelerates myocardial cell senescence through antagonism of Parkin

Cell senescence is associated with age-related pathological changes. Increasing evidence has revealed that mitophagy can selectively remove dysfunctional mitochondria. Overexpression of ubiquitin-specific protease 30 (USP30) has been documented to influence mitophagy and deubiquitination of mitochon...

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Detalles Bibliográficos
Autores principales: Pan, Wei, Wang, Yaowen, Bai, Xinyu, Yin, Yuehui, Dai, Limeng, Zhou, Hong, Wu, Qin, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295395/
https://www.ncbi.nlm.nih.gov/pubmed/34290230
http://dx.doi.org/10.1038/s41420-021-00546-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295395/
https://www.ncbi.nlm.nih.gov/pubmed/34290230
http://dx.doi.org/10.1038/s41420-021-00546-5

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