Competitive blocking of salivary gland [(18)F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study

BACKGROUND: PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radionuclides. With [(18)F]DCFPyL as a surrogate for PSMA-TRT, we report a novel meth...

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Detalles Bibliográficos
Autores principales: Roy, Jyoti, Warner, Blake M., Basuli, Falguni, Zhang, Xiang, Zheng, Changyu, Goldsmith, Corrine, Phelps, Tim, Wong, Karen, Ton, Anita T., Pieschl, Rick, White, Margaret E., Swenson, Rolf, Chiorini, John A., Choyke, Peter L., Lin, Frank I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295433/
https://www.ncbi.nlm.nih.gov/pubmed/34287731
http://dx.doi.org/10.1186/s13550-021-00803-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295433/
https://www.ncbi.nlm.nih.gov/pubmed/34287731
http://dx.doi.org/10.1186/s13550-021-00803-9

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