EGR1 dysregulation defines an inflammatory and leukemic program in cell trajectory of human-aged hematopoietic stem cells (HSC)

BACKGROUND: During aging, hematopoietic stem cells (HSC) lose progressively both their self-renewal and differentiation potential. The precise molecular mechanisms of this phenomenon are not well established. To uncover the molecular events underlying this event, we have performed a bioinformatics a...

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Detalles Bibliográficos
Autores principales: Desterke, Christophe, Bennaceur-Griscelli, Annelise, Turhan, Ali G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296523/
https://www.ncbi.nlm.nih.gov/pubmed/34294125
http://dx.doi.org/10.1186/s13287-021-02498-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296523/
https://www.ncbi.nlm.nih.gov/pubmed/34294125
http://dx.doi.org/10.1186/s13287-021-02498-0

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