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EGR1 dysregulation defines an inflammatory and leukemic program in cell trajectory of human-aged hematopoietic stem cells (HSC)

BACKGROUND: During aging, hematopoietic stem cells (HSC) lose progressively both their self-renewal and differentiation potential. The precise molecular mechanisms of this phenomenon are not well established. To uncover the molecular events underlying this event, we have performed a bioinformatics a...

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Detalles Bibliográficos
Autores principales:	Desterke, Christophe, Bennaceur-Griscelli, Annelise, Turhan, Ali G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296523/ https://www.ncbi.nlm.nih.gov/pubmed/34294125 http://dx.doi.org/10.1186/s13287-021-02498-0

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