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hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis

BACKGROUND: Human umbilical cord mesenchymal stem cell (hucMSC)-derived exosomes are recognized as novel cell-free therapeutic agents for inflammatory bowel disease (IBD), a condition caused by dysregulated intestinal mucosal immunity. In this event, macrophage pyroptosis, a process of cell death fo...

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Detalles Bibliográficos
Autores principales:	Cai, Xiu, Zhang, Zhi-yu, Yuan, Jin-tao, Ocansey, Dickson Kofi Wiredu, Tu, Qiang, Zhang, Xu, Qian, Hui, Xu, Wen-rong, Qiu, Wei, Mao, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296541/ https://www.ncbi.nlm.nih.gov/pubmed/34294138 http://dx.doi.org/10.1186/s13287-021-02492-6

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