The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene

BACKGROUND: In the search of genetic determinants of Duchenne muscular dystrophy (DMD) severity, LTBP4, a member of the latent TGF-β binding protein family, emerged as an important predictor of functional outcome trajectories in mice and humans. Nonsynonymous single-nucleotide polymorphisms in LTBP4...

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Detalles Bibliográficos
Autores principales: Licandro, Simonetta Andrea, Crippa, Luca, Pomarico, Roberta, Perego, Raffaella, Fossati, Gianluca, Leoni, Flavio, Steinkühler, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296708/
https://www.ncbi.nlm.nih.gov/pubmed/34294164
http://dx.doi.org/10.1186/s13395-021-00273-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296708/
https://www.ncbi.nlm.nih.gov/pubmed/34294164
http://dx.doi.org/10.1186/s13395-021-00273-6

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