DGKζ exerts greater control than DGKα over CD8(+) T cell activity and tumor inhibition

Two isoforms of diacylglycerol kinases (DGKs), DGKα and DGKζ, are primarily responsible for terminating DAG-mediated activation of Ras and PKCθ pathways in T cells. A direct comparison of tumor growth between mice lacking each isoform has not been undertaken. We evaluated the growth of three syngene...

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Detalles Bibliográficos
Autores principales: Gu, Junchen, Wang, Cindy, Cao, Carolyn, Huang, Jinwen, Holzhauer, Sandra, Desilva, Heshani, Wesley, Erin M., Evans, Douglas B., Benci, Joseph, Wichroski, Michael, Wee, Susan, Riese, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296965/
https://www.ncbi.nlm.nih.gov/pubmed/34350062
http://dx.doi.org/10.1080/2162402X.2021.1941566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296965/
https://www.ncbi.nlm.nih.gov/pubmed/34350062
http://dx.doi.org/10.1080/2162402X.2021.1941566

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