A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness

Recently, the highly mutated oncoprotein K-Ras4B (hereafter K-Ras) was shown to drive cancer cell stemness in conjunction with calmodulin (CaM). We previously showed that the covalent CaM inhibitor ophiobolin A (OphA) can potently inhibit K-Ras stemness activity. However, OphA, a fungus-derived natu...

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Detalles Bibliográficos
Autores principales: Okutachi, Sunday, Manoharan, Ganesh Babu, Kiriazis, Alexandros, Laurini, Christina, Catillon, Marie, McCormick, Frank, Yli-Kauhaluoma, Jari, Abankwa, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296985/
https://www.ncbi.nlm.nih.gov/pubmed/34307350
http://dx.doi.org/10.3389/fcell.2021.665673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296985/
https://www.ncbi.nlm.nih.gov/pubmed/34307350
http://dx.doi.org/10.3389/fcell.2021.665673

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