Spatial RNA Sequencing Identifies Robust Markers of Vulnerable and Resistant Human Midbrain Dopamine Neurons and Their Expression in Parkinson’s Disease

Defining transcriptional profiles of substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) dopamine neurons is critical to understanding their differential vulnerability in Parkinson’s Disease (PD). Here, we determine transcriptomes of human SNc and VTA dopamine neurons using LCM-seq...

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Detalles Bibliográficos
Autores principales: Aguila, Julio, Cheng, Shangli, Kee, Nigel, Cao, Ming, Wang, Menghan, Deng, Qiaolin, Hedlund, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297217/
https://www.ncbi.nlm.nih.gov/pubmed/34305528
http://dx.doi.org/10.3389/fnmol.2021.699562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297217/
https://www.ncbi.nlm.nih.gov/pubmed/34305528
http://dx.doi.org/10.3389/fnmol.2021.699562

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