The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model

People with Down syndrome (DS), caused by trisomy of chromosome 21 have a greatly increased risk of developing Alzheimer’s disease (AD). This is in part because of triplication of a chromosome 21 gene, APP. This gene encodes amyloid precursor protein, which is cleaved to form amyloid-β that accumula...

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Detalles Bibliográficos
Autores principales: Wu, Yixing, Whittaker, Heather T., Noy, Suzanna, Cleverley, Karen, Brault, Veronique, Herault, Yann, Fisher, Elizabeth M. C., Wiseman, Frances K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297773/
https://www.ncbi.nlm.nih.gov/pubmed/34292972
http://dx.doi.org/10.1371/journal.pone.0242236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297773/
https://www.ncbi.nlm.nih.gov/pubmed/34292972
http://dx.doi.org/10.1371/journal.pone.0242236

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