Dispersive effects and focused biodistribution of recombinant human hyaluronidase PH20: A locally acting and transiently active permeation enhancer

BACKGROUND: Recombinant human hyaluronidase PH20 (rHuPH20) facilitates the dispersion and absorption of subcutaneously administered therapeutic agents. This study aimed to characterize the transient, local action of rHuPH20 in the subcutaneous (SC) space using focused biodistribution and dye dispers...

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Detalles Bibliográficos
Autores principales: Kang, David W., Bittner, Beate, Sugarman, Barry J., Zepeda, Monica L., Printz, Marie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297837/
https://www.ncbi.nlm.nih.gov/pubmed/34292990
http://dx.doi.org/10.1371/journal.pone.0254765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297837/
https://www.ncbi.nlm.nih.gov/pubmed/34292990
http://dx.doi.org/10.1371/journal.pone.0254765

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