Constitutive activation of NF-κB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma

Aberrant NF-κB signaling fuels tumor growth in multiple human cancer types including both hematologic and solid malignancies. Chronic elevated alternative NF-κB signaling can be modeled in transgenic mice upon activation of a conditional NF-κB-inducing kinase (NIK) allele lacking the regulatory TRAF...

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Detalles Bibliográficos
Autores principales: Davis, Jennifer L., Thaler, Roman, Cox, Linda, Ricci, Biancamaria, Zannit, Heather M., Wan, Fei, Faccio, Roberta, Dudakovic, Amel, van Wijnen, Andre J., Veis, Deborah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297882/
https://www.ncbi.nlm.nih.gov/pubmed/34292968
http://dx.doi.org/10.1371/journal.pone.0254426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297882/
https://www.ncbi.nlm.nih.gov/pubmed/34292968
http://dx.doi.org/10.1371/journal.pone.0254426

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