Cargando…

Pharmacokinetics of Intraperitoneally Delivered Glucagon in Pigs: A Hypothesis of First Pass Metabolism

BACKGROUND AND OBJECTIVE: Artificial pancreases administering low-dose glucagon in addition to insulin have the scope to improve glucose control in patients with diabetes mellitus type 1. If such a device were to deliver both hormones intraperitoneally, it would mimic normal physiology, which may be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teigen, Ingrid Anna, Åm, Marte Kierulf, Carlsen, Sven Magnus, Christiansen, Sverre Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298214/ https://www.ncbi.nlm.nih.gov/pubmed/34100220 http://dx.doi.org/10.1007/s13318-021-00692-2

Ejemplares similares

Pharmacokinetics of glucagon after intravenous, intraperitoneal and subcutaneous administration in a pig model
por: Teigen, Ingrid Anna, et al.
Publicado: (2022)

Intraperitoneal and subcutaneous glucagon delivery in anaesthetized pigs: effects on circulating glucagon and glucose levels
por: Åm, Marte Kierulf, et al.
Publicado: (2020)

Vasodilatory effects of glucagon: A possible new approach to enhanced subcutaneous insulin absorption in artificial pancreas devices
por: Teigen, Ingrid Anna, et al.
Publicado: (2022)

Intraperitoneal, subcutaneous and intravenous glucagon delivery and subsequent glucose response in rats: a randomized controlled crossover trial
por: Dirnena-Fusini, Ilze, et al.
Publicado: (2018)

Intraperitoneal insulin administration in pigs: effect on circulating insulin and glucose levels
por: Dirnena-Fusini, Ilze, et al.
Publicado: (2021)

Physiological effects of intraperitoneal versus subcutaneous insulin infusion in patients with diabetes mellitus type 1: A systematic review and meta-analysis
por: Dirnena-Fusini, Ilze, et al.
Publicado: (2021)

Effect of sensor location on continuous intraperitoneal glucose sensing in an animal model
por: Åm, Marte Kierulf, et al.
Publicado: (2018)

A Review of the Current Challenges Associated with the Development of an Artificial Pancreas by a Double Subcutaneous Approach
por: Christiansen, Sverre Christian, et al.
Publicado: (2017)

Rotational intraperitoneal pressurized aerosol chemotherapy with paclitaxel and cisplatin: pharmacokinetics, tissue concentrations, and toxicities in a pig model
por: Park, Soo Jin, et al.
Publicado: (2022)

Does AMH Reflect Follicle Number Similarly in Women with and without PCOS?
por: Christiansen, Sverre C., et al.
Publicado: (2016)

Differences Between Flash Glucose Monitor and Fingerprick Measurements
por: Staal, Odd Martin, et al.
Publicado: (2018)

A phase I and pharmacokinetic study of intraperitoneal topotecan
por: Hofstra, L S, et al.
Publicado: (2001)

Intraperitoneal pharmacokinetics of vancomycin in patients on automated peritoneal dialysis
por: Lam, Edwin, et al.
Publicado: (2021)

Intraperitoneal administration of nesfatin-1 stimulates glucagon-like peptide-1 secretion in fasted mice
por: Tagawa, Noriko, et al.
Publicado: (2022)

In vivo Pharmacokinetic/Pharmacodynamic (PK/PD) Profiles of Tulathromycin in an Experimental Intraperitoneal Haemophilus parasuis Infection Model in Neutropenic Guinea Pigs
por: Guo, Li-li, et al.
Publicado: (2021)

Intraperitoneal clearance as a potential biomarker of cisplatin after intraperitoneal perioperative chemotherapy: a population pharmacokinetic study
por: Royer, B, et al.
Publicado: (2012)

First-Pass Meconium Samples from Healthy Term Vaginally-Delivered Neonates: An Analysis of the Microbiota
por: Hansen, Richard, et al.
Publicado: (2015)

PKQuest: measurement of intestinal absorption and first pass metabolism – application to human ethanol pharmacokinetics
por: Levitt, David G
Publicado: (2002)

Dose-Dependent Pharmacokinetics of Tofacitinib in Rats: Influence of Hepatic and Intestinal First-Pass Metabolism
por: Lee, Ji Sang, et al.
Publicado: (2019)

A phase I and pharmacokinetic study of intraperitoneal carboplatin and etoposide.
por: McClay, E. F., et al.
Publicado: (1993)

Preclinical Pharmacokinetic Evaluation of β-Lapachone: Characteristics of Oral Bioavailability and First-Pass Metabolism in Rats
por: Kim, Iksoo, et al.
Publicado: (2015)

Effect of Intraperitoneal (224)Radium-Labelled Microparticles on Compartmentalized Inflammation After Cytoreductive Surgery and Hypertherm Intraperitoneal Chemotherapy
por: Thorgersen, Ebbe Billmann, et al.
Publicado: (2023)

Pharmacokinetics of Intraperitoneal Vancomycin and Amikacin in Automated Peritoneal Dialysis Patients With Peritonitis
por: Falbo dos Reis, Pâmela, et al.
Publicado: (2021)

Pharmacokinetics of preoperative intraperitoneal 5-FU in patients with pancreatic ductal adenocarcinoma
por: Öman, Mikael, et al.
Publicado: (2021)

Steady-state first-pass perfusion (SSFPP): A 3D TWIST in myocardial first-pass perfusion imaging
por: Giri, Shivraman, et al.
Publicado: (2012)

Establishment of a Refined Oral Glucose Tolerance Test in Pigs, and Assessment of Insulin, Glucagon and Glucagon-Like Peptide-1 Responses
por: Manell, Elin, et al.
Publicado: (2016)

Pharmacokinetics, immunogenicity and bioactivity of the therapeutic antibody catumaxomab intraperitoneally administered to cancer patients
por: Ruf, Peter, et al.
Publicado: (2010)

Présent passé, passé présent
por: Ionesco, Eugène
Publicado: (1968)

The Pharmacokinetics of Drugs Delivered to the Upper Nasal Space
por: Shrewsbury, Stephen B.
Publicado: (2023)

Pharmacokinetics of the P-gp Inhibitor Tariquidar in Rats After Intravenous, Oral, and Intraperitoneal Administration
por: Matzneller, Peter, et al.
Publicado: (2018)

Interaction of Dasabuvir With Clopidogrel: Did Predictions by Physiologically Based Pharmacokinetics Modeling Pass the Test?
por: Shebley, Mohamad
Publicado: (2018)

HbA1c as screening for gestational diabetes mellitus in women with polycystic ovary syndrome
por: Odsæter, Ingrid Hov, et al.
Publicado: (2015)

Feeding Management and Albendazole Pharmacokinetics in Pigs
por: Ignacio, Alvarez Luis, et al.
Publicado: (2023)

Glucagon Receptor Signaling and Glucagon Resistance
por: Janah, Lina, et al.
Publicado: (2019)

Body Surface Area Predicts Plasma Oxaliplatin and Pharmacokinetic Advantage in Hyperthermic Intraoperative Intraperitoneal Chemotherapy
por: Leinwand, Joshua C., et al.
Publicado: (2013)

Pharmacokinetics and toxicity of carboplatin used for hyperthermic intraperitoneal chemotherapy (HIPEC) in treatment of epithelial ovarian cancer
por: Mikkelsen, Mette Schou, et al.
Publicado: (2020)

Intraperitoneally Administered Vancomycin in Patients with Peritoneal Dialysis-Associated Peritonitis: Population Pharmacokinetics and Dosing Implications
por: Hartinger, Jan Miroslav, et al.
Publicado: (2023)

Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected with Haemophilus parasuis
por: Zhang, Ling, et al.
Publicado: (2017)

Occupational Exposure during Intraperitoneal Pressurized Aerosol Chemotherapy Using Doxorubicin in a Pig Model
por: Jung, Wongeon, et al.
Publicado: (2023)

Passing the pmp exam: how to take it and pass it
por: McGary, Rudd
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_11eb3m5r2cuopoqj1gcnp0r9eh