Catalytic activity and stereoselectivity of engineered phosphotriesterases towards structurally different nerve agents in vitro

Highly toxic organophosphorus nerve agents, especially the extremely stable and persistent V-type agents such as VX, still pose a threat to the human population and require effective medical countermeasures. Engineered mutants of the Brevundimonas diminuta phosphotriesterase (BdPTE) exhibit enhanced...

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Detalles Bibliográficos
Autores principales: Köhler, Anja, Escher, Benjamin, Job, Laura, Koller, Marianne, Thiermann, Horst, Skerra, Arne, Worek, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298220/
https://www.ncbi.nlm.nih.gov/pubmed/34160649
http://dx.doi.org/10.1007/s00204-021-03094-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298220/
https://www.ncbi.nlm.nih.gov/pubmed/34160649
http://dx.doi.org/10.1007/s00204-021-03094-0

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