Validation of the in vitro comet assay for DNA cross-links and altered bases detection

Mechanistic toxicology is gaining weight for human health risk assessment. Different mechanistic assays are available, such as the comet assay, which detects DNA damage at the level of individual cells. However, the conventional alkaline version only detects strand breaks and alkali-labile sites. We...

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Detalles Bibliográficos
Autores principales: Muruzabal, Damián, Sanz-Serrano, Julen, Sauvaigo, Sylvie, Treillard, Bertrand, Olsen, Ann-Karin, López de Cerain, Adela, Vettorazzi, Ariane, Azqueta, Amaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298235/
https://www.ncbi.nlm.nih.gov/pubmed/34196753
http://dx.doi.org/10.1007/s00204-021-03102-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298235/
https://www.ncbi.nlm.nih.gov/pubmed/34196753
http://dx.doi.org/10.1007/s00204-021-03102-3

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