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Acquired ABC-transporter overexpression in cancer cells: transcriptional induction or Darwinian selection?
Acquired multidrug resistance (MDR) in tumor diseases has repeatedly been associated with overexpression of ATP-binding cassette transporters (ABC-transporters) such as P-glycoprotein. Both in vitro and in vivo data suggest that these efflux transporters can cause MDR, albeit its actual relevance fo...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298356/ https://www.ncbi.nlm.nih.gov/pubmed/34236499 http://dx.doi.org/10.1007/s00210-021-02112-3 |