Harmful R-loops are prevented via different cell cycle-specific mechanisms

Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by genome-wide analysis of conditional yeast mutants that the THO transcription complex, prevents R-loop formation in G1 and S-phase, whereas the Sen1 DNA-RNA helicase prevents them only...

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Detalles Bibliográficos
Autores principales: San Martin-Alonso, Marta, Soler-Oliva, María E., García-Rubio, María, García-Muse, Tatiana, Aguilera, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298424/
https://www.ncbi.nlm.nih.gov/pubmed/34294712
http://dx.doi.org/10.1038/s41467-021-24737-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298424/
https://www.ncbi.nlm.nih.gov/pubmed/34294712
http://dx.doi.org/10.1038/s41467-021-24737-x

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