Cargando…

Generation and first characterization of TRDC-knockout pigs lacking γδ T cells

The TRDC-locus encodes the T cell receptor delta constant region, one component of the γδ T cell receptor which is essential for development of γδ T cells. In contrast to peptide recognition by αβ T cells, antigens activating γδ T cells are mostly MHC independent and not well characterized. Therefor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Petersen, Bjoern, Kammerer, Robert, Frenzel, Antje, Hassel, Petra, Dau, Tung Huy, Becker, Roswitha, Breithaupt, Angele, Ulrich, Reiner Georg, Lucas-Hahn, Andrea, Meyers, Gregor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298467/ https://www.ncbi.nlm.nih.gov/pubmed/34294758 http://dx.doi.org/10.1038/s41598-021-94017-7

Ejemplares similares

Fetal Growth Retardation and Lack of Hypotaurine in Ezrin Knockout Mice
por: Nishimura, Tomohiro, et al.
Publicado: (2014)

Natural selection supports escape from concerted evolution of a recently duplicated CEACAM1 paralog in the ruminant CEA gene family
por: Hänske, Jana, et al.
Publicado: (2020)

Knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs
por: Kurtz, Stefanie, et al.
Publicado: (2021)

The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy
por: Legut, Mateusz, et al.
Publicado: (2015)

Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation
por: Muro, Ryunosuke, et al.
Publicado: (2023)

Role of γδ T Cells in Lung Inflammation
por: Born, Willi K., et al.
Publicado: (2009)

Interleukin‐17‐producing γδ T (γδ17) cells in inflammatory diseases
por: Akitsu, Aoi, et al.
Publicado: (2018)

Kidneys From α1,3-Galactosyltransferase Knockout/Human Heme Oxygenase-1/Human A20 Transgenic Pigs Are Protected From Rejection During Ex Vivo Perfusion With Human Blood
por: Ahrens, Hellen E., et al.
Publicado: (2015)

Mice Lacking γδ T Cells Exhibit Impaired Clearance of Pseudomonas aeruginosa Lung Infection and Excessive Production of Inflammatory Cytokines
por: Omar, Toka, et al.
Publicado: (2020)

The Aging of γδ T Cells
por: Xu, Weili, et al.
Publicado: (2020)

Invasion of Melanoma in Double Knockout Mice Lacking Tenascin‐X and Tenascin‐C
por: Matsumoto, Ken‐ichi, et al.
Publicado: (2002)

Monitoring Circulating γδ T Cells in Cancer Patients to Optimize γδ T Cell-Based Immunotherapy
por: Oberg, Hans-Heinrich, et al.
Publicado: (2014)

Imbalance of γδT17/γδTreg cells in the pathogenesis of allergic asthma induced by ovalbumin
por: Yang, Xia, et al.
Publicado: (2018)

Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity
por: Gully, Benjamin S., et al.
Publicado: (2021)

Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout)
por: Yamamoto, Takayuki, et al.
Publicado: (2020)

Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice
por: Mishima, Yuriko, et al.
Publicado: (2015)

γδ T cells take on CMV
por: Van Epps, Heather L.
Publicado: (2005)

γδ T-cells in HIV infection
por: Holt, NG, et al.
Publicado: (2012)

γδ T Cells and Their Potential for Immunotherapy
por: Wu, Yan-Ling, et al.
Publicado: (2014)

Chronic Inflammation and γδ T Cells
por: Fay, Nathan S., et al.
Publicado: (2016)

γδ T cells in cancer immunotherapy
por: Zou, Chang, et al.
Publicado: (2016)

Antiviral reactivities of γδ T cells
por: Poccia, Fabrizio, et al.
Publicado: (2005)

γδ T cells take the stage
por: Eriksson, Emily M, et al.
Publicado: (2019)

Editorial: γδ T Cells in Cancer
por: Coffelt, Seth B., et al.
Publicado: (2020)

Derivation of mimetic γδ T cells endowed with cancer recognition receptors from reprogrammed γδ T cell
por: Zeng, Jieming, et al.
Publicado: (2019)

Identification of the Ligands of TCRγδ by Screening the Immune Repertoire of γδT Cells From Patients With Tuberculosis
por: Li, Yuxia, et al.
Publicado: (2019)

CRISPR/Cas12a mediated knock-in of the Polled Celtic variant to produce a polled genotype in dairy cattle
por: Schuster, Felix, et al.
Publicado: (2020)

Pathology of African Swine Fever in Wild Boar Carcasses Naturally Infected with German Virus Variants
por: Sehl-Ewert, Julia, et al.
Publicado: (2022)

γδ lymphomatoid papulosis type D: A histologic mimic of primary cutaneous γδ T-cell lymphoma
por: Badje, Emilie Doré, et al.
Publicado: (2019)

Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells
por: Sumaria, Nital, et al.
Publicado: (2017)

Characterization of Donor Variability for γδ T Cell ex vivo Expansion and Development of an Allogeneic γδ T Cell Immunotherapy
por: Burnham, Rebecca E., et al.
Publicado: (2020)

Re-generation of cytotoxic γδT cells with distinctive signatures from human γδT-derived iPSCs
por: Murai, Nobuyuki, et al.
Publicado: (2023)

Analysis of knockout/knockin mice that express a mutant FasL lacking the intracellular domain
por: Lückerath, K, et al.
Publicado: (2009)

Lack of a Retinal Phenotype in a Syne-2/Nesprin-2 Knockout Mouse Model
por: Falk, Nathalie, et al.
Publicado: (2019)

Comparative Pathology of Domestic Pigs and Wild Boar Infected with the Moderately Virulent African Swine Fever Virus Strain “Estonia 2014”
por: Sehl, Julia, et al.
Publicado: (2020)

Protective Role of γδ T Cells in Cigarette Smoke and Influenza Infection
por: Hong, M. J., et al.
Publicado: (2017)

The γδ T Lymphocytes of the Perinatal Murine Thymus
por: Zorbas, Michelle I., et al.
Publicado: (1995)

Stoichiometry of the murine γδ T cell receptor
por: Hayes, Sandra M., et al.
Publicado: (2006)

γδ T Cell Immunotherapy—A Review
por: Kobayashi, Hirohito, et al.
Publicado: (2015)

The Role of γδ T Cells in Fibrotic Diseases
por: Bank, Ilan
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_f3ml8shk2qpgrjaa8uosn5jc2k