Afatinib induces pro-survival autophagy and increases sensitivity to apoptosis in stem-like HNSCC cells

Afatinib, a second-generation tyrosine kinase inhibitor (TKI), exerts its antitumor effects in head and neck squamous cell carcinoma (HNSCC) by inducing intrinsic apoptosis through suppression of mTORC1. However, the detailed mechanism and biological significance of afatinib-induced autophagy in HNS...

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Detalles Bibliográficos
Autores principales: Liu, Xianfang, Suo, Huiyuan, Zhou, Shengli, Hou, Zhenxing, Bu, Mingqiang, Liu, Xiuxiu, Xu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298552/
https://www.ncbi.nlm.nih.gov/pubmed/34294686
http://dx.doi.org/10.1038/s41419-021-04011-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298552/
https://www.ncbi.nlm.nih.gov/pubmed/34294686
http://dx.doi.org/10.1038/s41419-021-04011-0

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