Cargando…

Quantifying the contribution of Neanderthal introgression to the heritability of complex traits

Eurasians have ~2% Neanderthal ancestry, but we lack a comprehensive understanding of the genome-wide influence of Neanderthal introgression on modern human diseases and traits. Here, we quantify the contribution of introgressed alleles to the heritability of more than 400 diverse traits. We show th...

Descripción completa

Detalles Bibliográficos
Autores principales:	McArthur, Evonne, Rinker, David C., Capra, John A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298587/ https://www.ncbi.nlm.nih.gov/pubmed/34294692 http://dx.doi.org/10.1038/s41467-021-24582-y

Ejemplares similares

Neanderthal introgression reintroduced functional ancestral alleles lost in Eurasian populations
por: Rinker, David C., et al.
Publicado: (2020)

Archaic Introgression Shaped Human Circadian Traits
por: Velazquez-Arcelay, Keila, et al.
Publicado: (2023)

The lingering effects of Neanderthal introgression on human complex traits
por: Wei, Xinzhu, et al.
Publicado: (2023)

Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations
por: Koller, Dora, et al.
Publicado: (2022)

The role of Neanderthal introgression in liver cancer
por: Taravella Oill, Angela M., et al.
Publicado: (2022)

The Strength of Selection against Neanderthal Introgression
por: Juric, Ivan, et al.
Publicado: (2016)

A signature of Neanderthal introgression on molecular mechanisms of environmental responses
por: Findley, Anthony S., et al.
Publicado: (2021)

Neanderthal introgression in SCN9A impacts mechanical pain sensitivity
por: Faux, Pierre, et al.
Publicado: (2023)

Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals
por: Jagoda, Evelyn, et al.
Publicado: (2023)

Non-ultrametric phylogenetic trees shed new light on Neanderthal introgression
por: Tozzi, Arturo
Publicado: (2023)

Linking rare and common disease vocabularies by mapping between the human phenotype ontology and phecodes
por: McArthur, Evonne, et al.
Publicado: (2023)

Implementation of genome-wide complex trait analysis to quantify the heritability in multiple myeloma
por: Mitchell, Jonathan S., et al.
Publicado: (2015)

Quantifying the heritability of glioma using genome-wide complex trait analysis
por: Kinnersley, Ben, et al.
Publicado: (2015)

Quantifying the uncertainty in heritability
por: Furlotte, Nicholas A, et al.
Publicado: (2014)

Disease transmission and introgression can explain the long-lasting contact zone of modern humans and Neanderthals
por: Greenbaum, Gili, et al.
Publicado: (2019)

The MUC19 gene in Denisovans, Neanderthals, and Modern Humans: An Evolutionary History of Recurrent Introgression and Natural Selection
por: Villanea, Fernando A., et al.
Publicado: (2023)

Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders
por: Mozzi, Alessandra, et al.
Publicado: (2017)

A GWAS in the pandemic epicenter highlights the severe COVID-19 risk locus introgressed by Neanderthals
por: Breno, Matteo, et al.
Publicado: (2023)

Detection of Neanderthal Adaptively Introgressed Genetic Variants That Modulate Reporter Gene Expression in Human Immune Cells
por: Jagoda, Evelyn, et al.
Publicado: (2021)

MaLAdapt Reveals Novel Targets of Adaptive Introgression From Neanderthals and Denisovans in Worldwide Human Populations
por: Zhang, Xinjun, et al.
Publicado: (2023)

Haplotype Heritability Mapping Method Uncovers Missing Heritability of Complex Traits
por: Shirali, Masoud, et al.
Publicado: (2018)

Increased Transcript Complexity in Genes Associated with Chronic Obstructive Pulmonary Disease
por: Lackey, Lela, et al.
Publicado: (2015)

Beyond Missing Heritability: Prediction of Complex Traits
por: Makowsky, Robert, et al.
Publicado: (2011)

The Contribution of Neanderthals to Phenotypic Variation in Modern Humans
por: Dannemann, Michael, et al.
Publicado: (2017)

Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape
por: Li, Qing, et al.
Publicado: (2023)

Finding the missing heritability in pediatric obesity: the contribution of genome-wide complex trait analysis
por: Llewellyn, C H, et al.
Publicado: (2013)

No evidence of a Neanderthal contribution to modern human diversity
por: Hodgson, Jason A, et al.
Publicado: (2008)

Living with the Neanderthals
por: Goldman, Michael A.
Publicado: (2003)

Quantifying the heritability of belief formation
por: Vellani, Valentina, et al.
Publicado: (2022)

Re-evaluation of SNP heritability in complex human traits
por: Speed, Doug, et al.
Publicado: (2017)

Genetic Interactions with Sex Make a Relatively Small Contribution to the Heritability of Complex Traits in Mice
por: Krohn, Jon, et al.
Publicado: (2014)

Comparing chromatin contact maps at scale: methods and insights
por: Gunsalus, Laura M., et al.
Publicado: (2023)

Comparing chromatin contact maps at scale: methods and insights
por: Gunsalus, Laura M., et al.
Publicado: (2023)

Assessing the Heritability of Complex Traits in Humans: Methodological Challenges and Opportunities
por: Mayhew, Alexandra J., et al.
Publicado: (2017)

Leveraging population admixture to explain missing heritability of complex traits
por: Zaitlen, Noah, et al.
Publicado: (2014)

Archaeological Podocarpus tar supports the cognitive complexity of Neanderthals
por: Kozowyk, Paul R.B.
Publicado: (2023)

The influence of Neanderthal alleles on cytotoxic response
por: Akhtari, Farida S., et al.
Publicado: (2018)

Trait heritability in major transitions
por: Herron, Matthew D., et al.
Publicado: (2018)

Systematic design for trait introgression projects
por: Cameron, John N., et al.
Publicado: (2017)

Estimates of missing heritability for complex traits in Brown Swiss cattle
por: Román-Ponce, Sergio-Iván, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_vpgko1sqljiuti87v63ir28v2m