The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function

FBXL21 is a clock-controlled E3 ligase modulating circadian periodicity via subcellular-specific CRYPTOCHROME degradation. How FBXL21 regulates tissue-specific circadian physiology and what mechanism operates upstream is poorly understood. Here we report the sarcomere component TCAP as a cytoplasmic...

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Detalles Bibliográficos
Autores principales: Wirianto, Marvin, Yang, Jiah, Kim, Eunju, Gao, Song, Paudel, Keshav Raj, Choi, Jong Min, Choe, Jeehwan, Gloston, Gabrielle F., Ademoji, Precious, Parakramaweera, Randika, Jin, Jianping, Esser, Karyn A., Jung, Sung Yun, Geng, Yong-Jian, Lee, Hyun Kyoung, Chen, Zheng, Yoo, Seung-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299398/
https://www.ncbi.nlm.nih.gov/pubmed/32937135
http://dx.doi.org/10.1016/j.celrep.2020.108140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299398/
https://www.ncbi.nlm.nih.gov/pubmed/32937135
http://dx.doi.org/10.1016/j.celrep.2020.108140

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