Therapeutic Dose of Hydroxyurea-Induced Synaptic Abnormalities on the Mouse Spermatocyte

Hydroxyurea (HU) is a widely used pharmacological therapy for sickle cell disease (SCD). However, replication stress caused by HU has been shown to inhibit premeiotic S-phase DNA, leading to reproductive toxicity in germ cells. In this study, we administered the therapeutic doses of HU (i.e., 25 and...

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Detalles Bibliográficos
Autores principales: Fan, Xiaobo, Zhu, Yunxia, Wang, Naixin, Zhang, Bing, Zhang, Cui, Wang, Yanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299468/
https://www.ncbi.nlm.nih.gov/pubmed/34305635
http://dx.doi.org/10.3389/fphys.2021.666339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299468/
https://www.ncbi.nlm.nih.gov/pubmed/34305635
http://dx.doi.org/10.3389/fphys.2021.666339

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