Genetic mapping of novel modifiers for Apc(Min) induced intestinal polyps’ development using the genetic architecture power of the collaborative cross mice

BACKGROUND: Familial adenomatous polyposis is an inherited genetic disease, characterized by colorectal polyps. It is caused by inactivating mutations in the Adenomatous polyposis coli (Apc) gene. Mice carrying a nonsense mutation in the Apc gene at R850, which is designated Apc(Min/+) (Multiple int...

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Detalles Bibliográficos
Autores principales: Dorman, Alexandra, Binenbaum, Ilona, Abu-Toamih Atamni, Hanifa J., Chatziioannou, Aristotelis, Tomlinson, Ian, Mott, Richard, Iraqi, Fuad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299641/
https://www.ncbi.nlm.nih.gov/pubmed/34294033
http://dx.doi.org/10.1186/s12864-021-07890-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299641/
https://www.ncbi.nlm.nih.gov/pubmed/34294033
http://dx.doi.org/10.1186/s12864-021-07890-x

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