Cargando…

Genetic mapping of novel modifiers for Apc(Min) induced intestinal polyps’ development using the genetic architecture power of the collaborative cross mice

BACKGROUND: Familial adenomatous polyposis is an inherited genetic disease, characterized by colorectal polyps. It is caused by inactivating mutations in the Adenomatous polyposis coli (Apc) gene. Mice carrying a nonsense mutation in the Apc gene at R850, which is designated Apc(Min/+) (Multiple int...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dorman, Alexandra, Binenbaum, Ilona, Abu-Toamih Atamni, Hanifa J., Chatziioannou, Aristotelis, Tomlinson, Ian, Mott, Richard, Iraqi, Fuad A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299641/ https://www.ncbi.nlm.nih.gov/pubmed/34294033 http://dx.doi.org/10.1186/s12864-021-07890-x

Ejemplares similares

Genetic analysis of intestinal polyp development in Collaborative Cross mice carrying the Apc(Min/+) mutation
por: Dorman, Alexandra, et al.
Publicado: (2016)

Erratum to: Genetic analysis of intestinal polyp development in Collaborative Cross mice carrying the Apc Min/+ mutation
por: Dorman, Alexandra, et al.
Publicado: (2016)

Container-aided integrative QTL and RNA-seq analysis of Collaborative Cross mice supports distinct sex-oriented molecular modes of response in obesity
por: Binenbaum, Ilona, et al.
Publicado: (2020)

Efficient protocols and methods for high‐throughput utilization of the Collaborative Cross mouse model for dissecting the genetic basis of complex traits
por: Abu‐Toamih Atamni, Hanifa J., et al.
Publicado: (2019)

High-fat-diet induced development of increased fasting glucose levels and impaired response to intraperitoneal glucose challenge in the collaborative cross mouse genetic reference population
por: Atamni, Hanifa J. Abu-Toamih, et al.
Publicado: (2016)

Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice
por: Abu‐Toamih Atamni, Hanifa J., et al.
Publicado: (2018)

Assessing the host genetic background effects on type 2 diabetes and obesity development in response to mixed–oral bacteria and high‐fat diet using the collaborative cross mouse model
por: Karkar, Luna, et al.
Publicado: (2020)

Studying host genetic background effects on multimorbidity of intestinal cancer development, type 2 diabetes and obesity in response to oral bacterial infection and high‐fat diet using the collaborative cross (CC) lines
por: Milhem, Asal, et al.
Publicado: (2021)

Dissecting the Effect of Genetic Variation on the Hepatic Expression of Drug Disposition Genes across the Collaborative Cross Mouse Strains
por: Nachshon, Aharon, et al.
Publicado: (2016)

Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease
por: Lorè, Nicola Ivan, et al.
Publicado: (2020)

Modeling the quantitative nature of neurodevelopmental disorders using Collaborative Cross mice
por: Molenhuis, Remco T., et al.
Publicado: (2018)

Metabolomics of Apc( Min/+ ) mice genetically susceptible to intestinal cancer
por: Dazard, Jean-Eudes J, et al.
Publicado: (2014)

Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture
por: Levy, Roei, et al.
Publicado: (2015)

Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet
por: Pettan-Brewer, Christina, et al.
Publicado: (2011)

Exercise effects on polyp burden and immune markers in the Apc(Min)(/+) mouse model of intestinal tumorigenesis
por: McCLELLAN, JAMIE L., et al.
Publicado: (2014)

Role of Bone Marrow-Derived Stem Cells in Polyps Development in Mice with Apc(Min/+) Mutation
por: Barone, Michele, et al.
Publicado: (2015)

Berberine Inhibits Intestinal Polyps Growth in Apc (min/+) Mice via Regulation of Macrophage Polarization
por: Piao, Meiyu, et al.
Publicado: (2016)

Deficiency of Splicing Factor 1 (SF1) Reduces Intestinal Polyp Incidence in Apc(Min/)(+) Mice
por: Godavarthi, Jyotsna D., et al.
Publicado: (2020)

HASPIN kinase inhibitor CHR-6494 suppresses intestinal polyp development, cachexia, and hypogonadism in Apc(min/+) mice
por: Tanaka, Hiromitsu, et al.
Publicado: (2019)

Host genetic diversity influences the severity of Pseudomonas aeruginosa pneumonia in the Collaborative Cross mice
por: Lorè, Nicola Ivan, et al.
Publicado: (2015)

Acarbose improved survival for Apc(+/Min) mice
por: Dodds, Sherry G., et al.
Publicado: (2020)

Elevated Incidence of Polyp Formation in APC(Min/+)Msh2(−/−) Mice Is Independent of Nitric Oxide-Induced DNA Mutations
por: Belcheva, Antoaneta, et al.
Publicado: (2013)

Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells and modifies intestinal polyp development in Apc(Min/+) mice
por: Shimizu, Satomi, et al.
Publicado: (2014)

Differential Expression of MicroRNAs in Tumors from Chronically Inflamed or Genetic (APC(Min/+)) Models of Colon Cancer
por: Necela, Brian M., et al.
Publicado: (2011)

Winnie-APC(Min/+) Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation
por: De Santis, Stefania, et al.
Publicado: (2020)

A study of the influence of genetic variance and sex on the density and thickness of the calvarial bone in collaborative cross mice
por: Kaspersky, Uriel, et al.
Publicado: (2023)

Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling
por: Zhang, Junfang, et al.
Publicado: (2013)

Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in Apc(Min/+) mice
por: Huang, Guoxin, et al.
Publicado: (2017)

Unraveling the Host Genetic Background Effect on Internal Organ Weight Influenced by Obesity and Diabetes Using Collaborative Cross Mice
por: Ghnaim, Aya, et al.
Publicado: (2023)

Susceptibility to klebsiella pneumonaie infection in collaborative cross mice is a complex trait controlled by at least three loci acting at different time points
por: Vered, Karin, et al.
Publicado: (2014)

ERK activation drives intestinal tumorigenesis in Apc(min/)(+) mice
por: Lee, Sung Hee, et al.
Publicado: (2010)

OGA heterozygosity suppresses intestinal tumorigenesis in Apc(min/+) mice
por: Yang, Y R, et al.
Publicado: (2014)

Intestinal Peyer’s patches prevent tumorigenesis in Apc(Min/+) mice
por: Fujimoto, Kyoko, et al.
Publicado: (2015)

Lactonic Sophorolipids Increase Tumor Burden in Apc(min+/-) Mice
por: Callaghan, Breedge, et al.
Publicado: (2016)

Platelet status in cancer cachexia progression in Apc(Min/+) mice
por: Cunningham, Patrice, et al.
Publicado: (2023)

The effect of exercise on IL-6-induced cachexia in the Apc(Min/+) mouse
por: Puppa, Melissa J., et al.
Publicado: (2011)

Therapeutic utility of aspirin in the Apc(Min/+) murine model of colon carcinogenesis
por: Reuter, Brian K, et al.
Publicado: (2002)

Chemopreventive effects of berberine on intestinal tumor development in Apc(min/+) mice
por: Cao, Hailong, et al.
Publicado: (2013)

Olfactomedin 4 deletion induces colon adenocarcinoma in Apc(Min/+) mice
por: Liu, W, et al.
Publicado: (2016)

Dietary Uridine Decreases Tumorigenesis in the Apc(Min/+) Model of Intestinal Cancer
por: Field, Martha S, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_temi7pc5ep463h6pf1dlr4de7k