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Repeated but Not Single Administration of Ketamine Prolongs Increases of the Firing Activity of Norepinephrine and Dopamine Neurons

BACKGROUND: Clinical studies have shown that the rapid antidepressant effect of the glutamate N-methyl-D-aspartate receptor antagonist ketamine generally disappears within 1 week but can be maintained by repeated administration. Preclinical studies showed that a single ketamine injection immediately...

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Detalles Bibliográficos
Autores principales: Iro, Chidiebere M, Hamati, Rami, El Mansari, Mostafa, Blier, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299825/
https://www.ncbi.nlm.nih.gov/pubmed/33674836
http://dx.doi.org/10.1093/ijnp/pyab010