Effects of Serine or Threonine in the Active Site of Typical 2-Cys Prx on Hyperoxidation Susceptibility and on Chaperone Activity

Typical 2-Cys peroxiredoxins (2-Cys Prx) are ubiquitous Cys-based peroxidases, which are stable as decamers in the reduced state, and may dissociate into dimers upon disulfide bond formation. A peroxidatic Cys (C(P)) takes part of a catalytic triad, together with a Thr/Ser and an Arg. Previously, we...

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Detalles Bibliográficos
Autores principales: Tairum, Carlos A., Santos, Melina Cardoso, Breyer, Carlos Alexandre, de Oliveira, Ana Laura Pires, Cabrera, Vitoria Isabela Montanhero, Toledo-Silva, Guilherme, Mori, Gustavo Maruyama, Toyama, Marcos Hikari, Netto, Luis Eduardo Soares, de Oliveira, Marcos Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300647/
https://www.ncbi.nlm.nih.gov/pubmed/34202406
http://dx.doi.org/10.3390/antiox10071032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300647/
https://www.ncbi.nlm.nih.gov/pubmed/34202406
http://dx.doi.org/10.3390/antiox10071032

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