A Fine-Tuned Lipophilicity/Hydrophilicity Ratio Governs Antibacterial Potency and Selectivity of Bifurcated Halogen Bond-Forming NBTIs

Herein, we report the design of a focused library of novel bacterial topoisomerase inhibitors (NBTIs) based on innovative mainly monocyclic right-hand side fragments active against DNA gyrase and Topo IV. They exhibit a very potent and wide range of antibacterial activity, even against some of the m...

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Detalles Bibliográficos
Autores principales: Kolarič, Anja, Kokot, Maja, Hrast, Martina, Weiss, Matjaž, Zdovc, Irena, Trontelj, Jurij, Žakelj, Simon, Anderluh, Marko, Minovski, Nikola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300687/
https://www.ncbi.nlm.nih.gov/pubmed/34356782
http://dx.doi.org/10.3390/antibiotics10070862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300687/
https://www.ncbi.nlm.nih.gov/pubmed/34356782
http://dx.doi.org/10.3390/antibiotics10070862

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