The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING–IFN-β pathway

Evasion of host immunity is a hallmark of cancer, however mechanisms linking oncogenic mutations and immune escape are incompletely understood. Through loss-of-function screening of 1,001 tumor suppressor genes, we identified DAPK3 as a previously unrecognized driver of anti-tumor immunity through t...

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Detalles Bibliográficos
Autores principales: Takahashi, Mariko, Lio, Chan-Wang J., Campeau, Anaamika, Steger, Martin, Ay, Ferhat, Mann, Matthias, Gonzalez, David J., Jain, Mohit, Sharma, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300883/
https://www.ncbi.nlm.nih.gov/pubmed/33767426
http://dx.doi.org/10.1038/s41590-021-00896-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300883/
https://www.ncbi.nlm.nih.gov/pubmed/33767426
http://dx.doi.org/10.1038/s41590-021-00896-3

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