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The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING–IFN-β pathway
Evasion of host immunity is a hallmark of cancer, however mechanisms linking oncogenic mutations and immune escape are incompletely understood. Through loss-of-function screening of 1,001 tumor suppressor genes, we identified DAPK3 as a previously unrecognized driver of anti-tumor immunity through t...
Autores principales: | Takahashi, Mariko, Lio, Chan-Wang J., Campeau, Anaamika, Steger, Martin, Ay, Ferhat, Mann, Matthias, Gonzalez, David J., Jain, Mohit, Sharma, Sonia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300883/ https://www.ncbi.nlm.nih.gov/pubmed/33767426 http://dx.doi.org/10.1038/s41590-021-00896-3 |
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