Cargando…

3H-1,2-Dithiole-3-Thione Protects Lens Epithelial Cells against Fructose-Induced Epithelial-Mesenchymal Transition via Activation of AMPK to Eliminate AKR1B1-Induced Oxidative Stress in Diabetes Mellitus

Studies demonstrated that the receptor of advanced glycation end products (RAGE) induced epithelial-mesenchymal transition (EMT) formation in the lens epithelial cells (LECs) of diabetic cataracts. This work investigated how 3H-1,2-dithiole-3-thione (D3T) reduces EMT formation in LECs of the fructos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Tsung-Tien, Chen, Ying-Ying, Ho, Chiu-Yi, Yeh, Tung-Chen, Sun, Gwo-Ching, Tseng, Ching-Jiunn, Cheng, Pei-Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301018/ https://www.ncbi.nlm.nih.gov/pubmed/34356319 http://dx.doi.org/10.3390/antiox10071086

Ejemplares similares

AKR1B1-Induced Epithelial–Mesenchymal Transition Mediated by RAGE-Oxidative Stress in Diabetic Cataract Lens
por: Wu, Tsung-Tien, et al.
Publicado: (2020)

Thieno[3,4-d][1,3]dithiole-2-thione
por: Wen, Hua-wen, et al.
Publicado: (2011)

Synthesis and Reactivity of 3H-1,2-dithiole-3-thiones
por: Rakitin, Oleg A.
Publicado: (2021)

2,5-Bis(1,3-dithiol-2-ylidene)-1,3-dithiolane-4-thione
por: Ueda, Kazumasa, et al.
Publicado: (2011)

1,2-dithiol-3-thione and dithioester analogues: potential radioprotectors.
por: Teicher, B. A., et al.
Publicado: (1990)

4,5-Diferrocenyl-1,2-dithiole-3-thione
por: Sánchez-García, Jessica J., et al.
Publicado: (2022)

Blocking of SGLT2 to Eliminate NADPH-Induced Oxidative Stress in Lenses of Animals with Fructose-Induced Diabetes Mellitus
por: Chen, Ying-Ying, et al.
Publicado: (2022)

5-Isopropylidene-1,3-dithiolo[4,5-d][1,3]dithiole-2-thione
por: Tomura, Masaaki, et al.
Publicado: (2009)

Dapagliflozin Prevents NOX- and SGLT2-Dependent Oxidative Stress in Lens Cells Exposed to Fructose-Induced Diabetes Mellitus
por: Chen, Ying-Ying, et al.
Publicado: (2019)

4-Bromo-5-[(2-bromoethyl)sulfanyl]-1,3-dithiole-2-thione
por: Ding, Jing-Jing, et al.
Publicado: (2009)

Inhibition of NLRP3 Inflammasome Activation by 3H-1,2-Dithiole-3-Thione: A Potential Therapeutic Approach for Psoriasis Treatment
por: Shih, Meng-Chieh, et al.
Publicado: (2023)

Resveratrol Inhibition of Rac1-Derived Reactive Oxygen Species by AMPK Decreases Blood Pressure in a Fructose-Induced Rat Model of Hypertension
por: Cheng, Pei-Wen, et al.
Publicado: (2016)

Studies with 1,2-dithiole-3-thione as a chemoprotector of hydroquinone-induced toxicity to DBA/2-derived bone marrow stromal cells.
por: Twerdok, L E, et al.
Publicado: (1993)

5-(4,5-Diiodo-1,3-dithiol-2-ylidene)-4′,5′-bis(methylsulfanyl)-2,2′-bi-1,3-dithiole-4(5H)-thione
por: Ueda, Kazumasa, et al.
Publicado: (2009)

Macrophage Activity under Hyperglycemia: A Study of the Effect of Resveratrol and 3H-1,2-Dithiole-3-thione on Potential Polarization
por: Manríquez-Núñez, Josué, et al.
Publicado: (2023)

The Antioxidant 3H-1,2-Dithiole-3-Thione Potentiates Advanced Glycation End-Product-Induced Oxidative Stress in SH-SY5Y Cells
por: Pazdro, Robert, et al.
Publicado: (2012)

CX3CR1-microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats
por: Ho, Chiu-Yi, et al.
Publicado: (2020)

3H-1,2-Dithiole-3-thione Suppresses LPS-induced Proinflammatory Responses in Macrophages: Potential Involvement of Antioxidant Induction, NF-κB, and Nrf2
por: Zhu, Hong, et al.
Publicado: (2022)

2-(1,3-Dithiol-2-ylidene)-1,3-dithiole-4-carbaldehyde
por: Zeller, Matthias, et al.
Publicado: (2013)

Roles of AKR1C3 in malignancy
por: Xiao, Xin-Zhu, et al.
Publicado: (2021)

Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents.
por: Doherty, G. P., et al.
Publicado: (1998)

Polydatin inhibits ZEB1‐invoked epithelial‐mesenchymal transition in fructose‐induced liver fibrosis
por: Zhao, Xiaojuan, et al.
Publicado: (2020)

1-(2-Fluorobenzyl)quinolinium bis(2-sulfanylidene-1,3-dithiole-4,5-dithiolato-κ(2) S,S′)nickelate(III)
por: Shan, Wen-Wen, et al.
Publicado: (2011)

Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma
por: Zhu, Pengfei, et al.
Publicado: (2021)

High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells
por: Chen, Yu-Ching, et al.
Publicado: (2016)

The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death
por: Li, Wei, et al.
Publicado: (2016)

Synthesis and structures of dinuclear palladium complexes with 1,3-benzimidazolidine-2-thione and 1,3-imidazoline-2-thione
por: Lobana, Tarlok S., et al.
Publicado: (2023)

3H-1,2-dithiole-3-thione protects retinal pigment epithelium cells against Ultra-violet radiation via activation of Akt-mTORC1-dependent Nrf2-HO-1 signaling
por: Li, Ke-ran, et al.
Publicado: (2016)

Synthesis of Thieno[2,3-d]-1,3-dithiol-2-thiones from Thieno[2,3-d]-1,2,3-thiadiazoles: Matryoshka-type autoclave for high-temperature, high-pressure thermolysis microscale reactions†
por: Jordis, Ulrich, et al.
Publicado: (2002)

1,2-Bis(1,3-dithiol-2-ylidene)hydrazine
por: Li, Hong-ai, et al.
Publicado: (2008)

Rh(II)‐Catalyzed De‐symmetrization of Ethane‐1,2‐dithiol and Propane‐1,3‐dithiol Yields Metallo‐β‐lactamase Inhibitors
por: Krasavin, Mikhail, et al.
Publicado: (2021)

1,3-Dibenzylimidazolidine-2-thione
por: Mietlarek-Kropidłowska, Anna, et al.
Publicado: (2012)

AKR1C1-3, notably AKR1C3, are distinct biomarkers for liver cancer diagnosis and prognosis: Database mining in malignancies
por: Zhao, Shou-Feng, et al.
Publicado: (2019)

Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways
por: Li, Yu-Cheng, et al.
Publicado: (2018)

6,7,8,9,10,11,12,13-Octahydro-5H-1,3-dithiole[4,5-b][1,4]dithiacyclotridecine-2-thione
por: Heshmatpour, Felora, et al.
Publicado: (2008)

4-(Pyridin-2-yl)-1,3-dithiol-2-one
por: Zhou, Guoquan, et al.
Publicado: (2012)

Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases
por: Rižner, Tea Lanišnik
Publicado: (2012)

3-tert-Butyl-1H-isochromene-1-thione
por: Khan, F. Nawaz, et al.
Publicado: (2010)

1-(3,4-Dichlorobenzyl)pyridinium bis(2-sulfanylidene-1,3-dithiole-4,5-dithiolato-κ(2) S,S′)nickelate(III)
por: Liu, Guang-Xiang
Publicado: (2011)

AKR1C3 Overexpression Mediates Methotrexate Resistance in Choriocarcinoma Cells
por: Zhao, Jing, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pg4hkiicor3k1mlclnkhbacjhd