Cargando…

TGF-β1 Facilitates TAp63α Protein Lysosomal Degradation to Promote Pancreatic Cancer Cell Migration

SIMPLE SUMMARY: Numerous studies demonstrate that the activation of transforming growth factor-β (TGF-β) signaling is a critical driving force for promoting cancer cell migration and tumor metastasis. Our recent study indicates that TGF-β1 promotes FBXO3-mediated ΔNp63α protein degradation to facili...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Guohui, Chen, Jie, Wang, Dongbo, Li, Qiao, Yang, Xiaojiao, Wang, Jindan, Pan, Zhiyong, Xiao, Zhi-Xiong Jim, Yi, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301043/ https://www.ncbi.nlm.nih.gov/pubmed/34203341 http://dx.doi.org/10.3390/biology10070597

Ejemplares similares

Correction: Gao et al. TGF-β1 Facilitates TAp63α Protein Lysosomal Degradation to Promote Pancreatic Cancer Cell Migration. Biology 2021, 10, 597
por: Gao, Guohui, et al.
Publicado: (2022)

NAD(P)H Quinone Oxidoreductase Protects TAp63γ from Proteasomal Degradation and Regulates TAp63γ-Dependent Growth Arrest
por: Hershkovitz Rokah, Oshrat, et al.
Publicado: (2010)

TAp63: The fountain of youth
por: Su, Xiaohua, et al.
Publicado: (2009)

TAp63 regulates oncogenic miR-155 to mediate migration and tumour growth
por: Mattiske, Sam, et al.
Publicado: (2013)

TAp63γ influences mouse cartilage development
por: Wang, Qian, et al.
Publicado: (2020)

Hsp70 acts as a fine-switch that controls E3 ligase CHIP-mediated TAp63 and ΔNp63 ubiquitination and degradation
por: Wu, H Helena, et al.
Publicado: (2021)

Correction for: TAp63γ influences mouse cartilage development
por: Wang, Qian, et al.
Publicado: (2020)

Myoblasts rely on TAp63 to control basal mitochondria respiration
por: Ciuffoli, Veronica, et al.
Publicado: (2018)

TAp63 determines the fate of oocytes against DNA damage
por: Luan, Yi, et al.
Publicado: (2022)

Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor
por: Zhang, Li, et al.
Publicado: (2013)

TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway
por: Su, X, et al.
Publicado: (2017)

Pin1 and JNK1 cooperatively modulate TAp63γ
por: Fan, Xueying, et al.
Publicado: (2021)

ΔNp63 to TAp63 expression ratio as a potential molecular marker for cervical cancer prognosis
por: Park, Sunyoung, et al.
Publicado: (2019)

DNA Demethylation Switches Oncogenic ΔNp63 to Tumor Suppressive TAp63 in Squamous Cell Carcinoma
por: Pokorna, Zuzana, et al.
Publicado: (2022)

TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
por: Wang, Chunmei, et al.
Publicado: (2018)

Correction: ΔNp63 to TAp63 expression ratio as a potential molecular marker for cervical cancer prognosis
por: Park, Sunyoung, et al.
Publicado: (2019)

Pentabromopseudilin: a myosin V inhibitor suppresses TGF-β activity by recruiting the type II TGF-β receptor to lysosomal degradation
por: Shih-Wei, Wang, et al.
Publicado: (2018)

Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63
por: von Grabowiecki, Yannick, et al.
Publicado: (2016)

Noncanonical TGF-β signaling leads to FBXO3-mediated degradation of ΔNp63α promoting breast cancer metastasis and poor clinical prognosis
por: Niu, Mengmeng, et al.
Publicado: (2021)

Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma
por: Yamaki, Tomohiro, et al.
Publicado: (2013)

OTX2 regulates the expression of TAp63 leading to macular and cochlear neuroepithelium development
por: Palombo, Ramona, et al.
Publicado: (2015)

p53 and TAp63 Promote Keratinocyte Proliferation and Differentiation in Breeding Tubercles of the Zebrafish
por: Fischer, Boris, et al.
Publicado: (2014)

p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes
por: Marcet-Ortega, Marina, et al.
Publicado: (2017)

SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes
por: Li, Min-Zhe, et al.
Publicado: (2018)

NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle
por: Heyne, Kristina, et al.
Publicado: (2010)

TAp63 suppress metastasis via miR-133b in colon cancer cells
por: Lin, C W, et al.
Publicado: (2014)

Negative feedback between TAp63 and Mir-133b mediates colorectal cancer suppression
por: Dai, Jing, et al.
Publicado: (2016)

Inactivation of tumor suppressor TAp63 by hepatitis B virus X protein in hepatocellular carcinoma
por: Xie, Bangxiang, et al.
Publicado: (2022)

The Human Papillomavirus E6 Oncogene Represses a Cell Adhesion Pathway and Disrupts Focal Adhesion through Degradation of TAp63β upon Transformation
por: Ben Khalifa, Youcef, et al.
Publicado: (2011)

Loss of TACSTD2 contributed to squamous cell carcinoma progression through attenuating TAp63-dependent apoptosis
por: Wang, F, et al.
Publicado: (2014)

TAp63γ and ΔNp63β Promote Osteoblastic Differentiation of Human Mesenchymal Stem Cells: Regulation by Vitamin D3 Metabolites
por: Curtis, Kevin M., et al.
Publicado: (2015)

TAp63γ and ΔNp63γ are regulated by RBM38 via mRNA stability and have an opposing function in growth suppression
por: Yan, Wensheng, et al.
Publicado: (2017)

ΔNp63 silencing, DNA methylation shifts, and epithelial-mesenchymal transition resulted from TAp63 genome editing in squamous cell carcinoma
por: Katoh, Iyoko, et al.
Publicado: (2023)

TAp63α targeting of Lgr5 mediates colorectal cancer stem cell properties and sulforaphane inhibition
por: Chen, Yue, et al.
Publicado: (2020)

GSK-3β protects fetal oocytes from premature death via modulating TAp63 expression in mice
por: Wen, Jia, et al.
Publicado: (2019)

Comment on ‘TAp63 suppress metastasis via miR-133b in colon cancer cells'
por: Cristobal, I, et al.
Publicado: (2014)

C-Abl is not actıvated in DNA damage-induced and Tap63-mediated oocyte apoptosıs in human ovary
por: Bildik, Gamze, et al.
Publicado: (2018)

Targeting of ΔNp63α by miR‐522 promotes the migration of breast epithelial cells
por: Dong, Yuanyuan, et al.
Publicado: (2021)

Agmatinase facilitates the tumorigenesis of pancreatic adenocarcinoma through the TGFβ/Smad pathway
por: Zhang, Yue, et al.
Publicado: (2022)

ΔNp63α facilitates proliferation and migration, and modulates the chromatin landscape in intrahepatic cholangiocarcinoma cells
por: Peng, Anghui, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tgh8vi3d8jf0o8j49bv1sur8ui