β-Hydroxybutyrate, a Ketone Body, Potentiates the Antioxidant Defense via Thioredoxin 1 Upregulation in Cardiomyocytes

Thioredoxin 1 (Trx1) is a major antioxidant that acts adaptively to protect the heart during the development of diabetic cardiomyopathy. The molecular mechanism(s) responsible for regulating the Trx1 level and/or activity during diabetic cardiomyopathy is unknown. β-hydroxybutyrate (βHB), a major ke...

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Detalles Bibliográficos
Autores principales: Oka, Shin-ichi, Tang, Fan, Chin, Adave, Ralda, Guersom, Xu, Xiaoyong, Hu, Chengchen, Yang, Zhi, Abdellatif, Maha, Sadoshima, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301070/
https://www.ncbi.nlm.nih.gov/pubmed/34356388
http://dx.doi.org/10.3390/antiox10071153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301070/
https://www.ncbi.nlm.nih.gov/pubmed/34356388
http://dx.doi.org/10.3390/antiox10071153

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