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Thermosensory Transient Receptor Potential Ion Channels and Asthma
Asthma is a widespread chronic disease of the bronchopulmonary system with a heterogeneous course due to the complex etiopathogenesis. Natural-climatic and anthropogenic factors play an important role in the development and progression of this pathology. The reception of physical and chemical enviro...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301310/ https://www.ncbi.nlm.nih.gov/pubmed/34356881 http://dx.doi.org/10.3390/biomedicines9070816 |
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author | Kytikova, Oxana Yu. Novgorodtseva, Tatyana P. Denisenko, Yulia K. Naumov, Denis E. Gvozdenko, Tatyana A. Perelman, Juliy M. |
author_facet | Kytikova, Oxana Yu. Novgorodtseva, Tatyana P. Denisenko, Yulia K. Naumov, Denis E. Gvozdenko, Tatyana A. Perelman, Juliy M. |
author_sort | Kytikova, Oxana Yu. |
collection | PubMed |
description | Asthma is a widespread chronic disease of the bronchopulmonary system with a heterogeneous course due to the complex etiopathogenesis. Natural-climatic and anthropogenic factors play an important role in the development and progression of this pathology. The reception of physical and chemical environmental stimuli and the regulation of body temperature are mediated by thermosensory channels, members of a subfamily of transient receptor potential (TRP) ion channels. It has been found that genes encoding vanilloid, ankyrin, and melastatin TRP channels are involved in the development of some asthma phenotypes and in the formation of exacerbations of this pathology. The review summarizes modern views on the role of high and low temperatures in airway inflammation in asthma. The participation of thermosensory TRP channels (vanilloid, ankyrin, and melastatin TRP channels) in the reaction to high and low temperatures and air humidity as well as in the formation of bronchial hyperreactivity and respiratory symptoms accompanying asthma is described. The genetic aspects of the functioning of thermosensory TRP channels are discussed. It is shown that new methods of treatment of asthma exacerbations caused by the influence of temperature and humidity should be based on the regulation of channel activity. |
format | Online Article Text |
id | pubmed-8301310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83013102021-07-24 Thermosensory Transient Receptor Potential Ion Channels and Asthma Kytikova, Oxana Yu. Novgorodtseva, Tatyana P. Denisenko, Yulia K. Naumov, Denis E. Gvozdenko, Tatyana A. Perelman, Juliy M. Biomedicines Review Asthma is a widespread chronic disease of the bronchopulmonary system with a heterogeneous course due to the complex etiopathogenesis. Natural-climatic and anthropogenic factors play an important role in the development and progression of this pathology. The reception of physical and chemical environmental stimuli and the regulation of body temperature are mediated by thermosensory channels, members of a subfamily of transient receptor potential (TRP) ion channels. It has been found that genes encoding vanilloid, ankyrin, and melastatin TRP channels are involved in the development of some asthma phenotypes and in the formation of exacerbations of this pathology. The review summarizes modern views on the role of high and low temperatures in airway inflammation in asthma. The participation of thermosensory TRP channels (vanilloid, ankyrin, and melastatin TRP channels) in the reaction to high and low temperatures and air humidity as well as in the formation of bronchial hyperreactivity and respiratory symptoms accompanying asthma is described. The genetic aspects of the functioning of thermosensory TRP channels are discussed. It is shown that new methods of treatment of asthma exacerbations caused by the influence of temperature and humidity should be based on the regulation of channel activity. MDPI 2021-07-14 /pmc/articles/PMC8301310/ /pubmed/34356881 http://dx.doi.org/10.3390/biomedicines9070816 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kytikova, Oxana Yu. Novgorodtseva, Tatyana P. Denisenko, Yulia K. Naumov, Denis E. Gvozdenko, Tatyana A. Perelman, Juliy M. Thermosensory Transient Receptor Potential Ion Channels and Asthma |
title | Thermosensory Transient Receptor Potential Ion Channels and Asthma |
title_full | Thermosensory Transient Receptor Potential Ion Channels and Asthma |
title_fullStr | Thermosensory Transient Receptor Potential Ion Channels and Asthma |
title_full_unstemmed | Thermosensory Transient Receptor Potential Ion Channels and Asthma |
title_short | Thermosensory Transient Receptor Potential Ion Channels and Asthma |
title_sort | thermosensory transient receptor potential ion channels and asthma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301310/ https://www.ncbi.nlm.nih.gov/pubmed/34356881 http://dx.doi.org/10.3390/biomedicines9070816 |
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