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Thermosensory Transient Receptor Potential Ion Channels and Asthma

Asthma is a widespread chronic disease of the bronchopulmonary system with a heterogeneous course due to the complex etiopathogenesis. Natural-climatic and anthropogenic factors play an important role in the development and progression of this pathology. The reception of physical and chemical enviro...

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Autores principales: Kytikova, Oxana Yu., Novgorodtseva, Tatyana P., Denisenko, Yulia K., Naumov, Denis E., Gvozdenko, Tatyana A., Perelman, Juliy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301310/
https://www.ncbi.nlm.nih.gov/pubmed/34356881
http://dx.doi.org/10.3390/biomedicines9070816
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author Kytikova, Oxana Yu.
Novgorodtseva, Tatyana P.
Denisenko, Yulia K.
Naumov, Denis E.
Gvozdenko, Tatyana A.
Perelman, Juliy M.
author_facet Kytikova, Oxana Yu.
Novgorodtseva, Tatyana P.
Denisenko, Yulia K.
Naumov, Denis E.
Gvozdenko, Tatyana A.
Perelman, Juliy M.
author_sort Kytikova, Oxana Yu.
collection PubMed
description Asthma is a widespread chronic disease of the bronchopulmonary system with a heterogeneous course due to the complex etiopathogenesis. Natural-climatic and anthropogenic factors play an important role in the development and progression of this pathology. The reception of physical and chemical environmental stimuli and the regulation of body temperature are mediated by thermosensory channels, members of a subfamily of transient receptor potential (TRP) ion channels. It has been found that genes encoding vanilloid, ankyrin, and melastatin TRP channels are involved in the development of some asthma phenotypes and in the formation of exacerbations of this pathology. The review summarizes modern views on the role of high and low temperatures in airway inflammation in asthma. The participation of thermosensory TRP channels (vanilloid, ankyrin, and melastatin TRP channels) in the reaction to high and low temperatures and air humidity as well as in the formation of bronchial hyperreactivity and respiratory symptoms accompanying asthma is described. The genetic aspects of the functioning of thermosensory TRP channels are discussed. It is shown that new methods of treatment of asthma exacerbations caused by the influence of temperature and humidity should be based on the regulation of channel activity.
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spelling pubmed-83013102021-07-24 Thermosensory Transient Receptor Potential Ion Channels and Asthma Kytikova, Oxana Yu. Novgorodtseva, Tatyana P. Denisenko, Yulia K. Naumov, Denis E. Gvozdenko, Tatyana A. Perelman, Juliy M. Biomedicines Review Asthma is a widespread chronic disease of the bronchopulmonary system with a heterogeneous course due to the complex etiopathogenesis. Natural-climatic and anthropogenic factors play an important role in the development and progression of this pathology. The reception of physical and chemical environmental stimuli and the regulation of body temperature are mediated by thermosensory channels, members of a subfamily of transient receptor potential (TRP) ion channels. It has been found that genes encoding vanilloid, ankyrin, and melastatin TRP channels are involved in the development of some asthma phenotypes and in the formation of exacerbations of this pathology. The review summarizes modern views on the role of high and low temperatures in airway inflammation in asthma. The participation of thermosensory TRP channels (vanilloid, ankyrin, and melastatin TRP channels) in the reaction to high and low temperatures and air humidity as well as in the formation of bronchial hyperreactivity and respiratory symptoms accompanying asthma is described. The genetic aspects of the functioning of thermosensory TRP channels are discussed. It is shown that new methods of treatment of asthma exacerbations caused by the influence of temperature and humidity should be based on the regulation of channel activity. MDPI 2021-07-14 /pmc/articles/PMC8301310/ /pubmed/34356881 http://dx.doi.org/10.3390/biomedicines9070816 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kytikova, Oxana Yu.
Novgorodtseva, Tatyana P.
Denisenko, Yulia K.
Naumov, Denis E.
Gvozdenko, Tatyana A.
Perelman, Juliy M.
Thermosensory Transient Receptor Potential Ion Channels and Asthma
title Thermosensory Transient Receptor Potential Ion Channels and Asthma
title_full Thermosensory Transient Receptor Potential Ion Channels and Asthma
title_fullStr Thermosensory Transient Receptor Potential Ion Channels and Asthma
title_full_unstemmed Thermosensory Transient Receptor Potential Ion Channels and Asthma
title_short Thermosensory Transient Receptor Potential Ion Channels and Asthma
title_sort thermosensory transient receptor potential ion channels and asthma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301310/
https://www.ncbi.nlm.nih.gov/pubmed/34356881
http://dx.doi.org/10.3390/biomedicines9070816
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