Cargando…

In Vitro Evaluation of a Nanoparticle-Based mRNA Delivery System for Cells in the Joint

Biodegradable and bioresponsive polymer-based nanoparticles (NPs) can be used for oligonucleotide delivery, making them a promising candidate for mRNA-based therapeutics. In this study, we evaluated and optimized the efficiency of a cationic, hyperbranched poly(amidoamine)s-based nanoparticle system...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sturm, Lisa, Schwemberger, Bettina, Menzel, Ursula, Häckel, Sonja, Albers, Christoph E., Plank, Christian, Rip, Jaap, Alini, Mauro, Traweger, Andreas, Grad, Sibylle, Basoli, Valentina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301349/ https://www.ncbi.nlm.nih.gov/pubmed/34356857 http://dx.doi.org/10.3390/biomedicines9070794

Ejemplares similares

In Vitro Characterization of a Tissue Renin-Angiotensin System in Human Nucleus Pulposus Cells
por: Saravi, Babak, et al.
Publicado: (2022)

Isolation of high‐quality RNA from intervertebral disc tissue via pronase predigestion and tissue pulverization
por: Caprez, Stephanie, et al.
Publicado: (2018)

Differential Regulation of circRNA, miRNA, and piRNA during Early Osteogenic and Chondrogenic Differentiation of Human Mesenchymal Stromal Cells
por: Della Bella, Elena, et al.
Publicado: (2020)

Proinflammatory intervertebral disc cell and organ culture models induced by tumor necrosis factor alpha
por: Du, Jie, et al.
Publicado: (2020)

Mesenchymal Stem Cell Homing Into Intervertebral Discs Enhances the Tie2-positive Progenitor Cell Population, Prevents Cell Death, and Induces a Proliferative Response
por: Wangler, Sebastian, et al.
Publicado: (2019)

Effect of glucose depletion and fructose administration during chondrogenic commitment in human bone marrow-derived stem cells
por: Zuncheddu, Daniele, et al.
Publicado: (2022)

Hypoxic stress enhances extension and branching of dorsal root ganglion neuronal outgrowth
por: Ma, Junxuan, et al.
Publicado: (2020)

Small molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidence
por: Zhang, Penghui, et al.
Publicado: (2022)

Fibrin-Hyaluronic Acid Hydrogel (RegenoGel) with Fibroblast Growth Factor-18 for In Vitro 3D Culture of Human and Bovine Nucleus Pulposus Cells
por: Häckel, Sonja, et al.
Publicado: (2019)

Uncovering the secretome of mesenchymal stromal cells exposed to healthy, traumatic, and degenerative intervertebral discs: a proteomic analysis
por: Wangler, Sebastian, et al.
Publicado: (2021)

Direct and Intervertebral DiscMediated Sensitization of Dorsal Root Ganglion Neurons by Hypoxia and Low pH
por: Ma, Junxuan, et al.
Publicado: (2020)

Global Responses of Il-1β-Primed 3D Tendon Constructs to Treatment with Pulsed Electromagnetic Fields
por: Gehwolf, Renate, et al.
Publicado: (2019)

Establishment of an Ex Vivo Inflammatory Osteoarthritis Model With Human Osteochondral Explants
por: Li, Kaihu, et al.
Publicado: (2021)

Anti-inflammatory and pro-anabolic effects of 5-aminosalicylic acid on human inflammatory osteoarthritis models
por: Li, Kaihu, et al.
Publicado: (2022)

Effect of expansion media and fibronectin coating on growth and chondrogenic differentiation of human bone marrow-derived mesenchymal stromal cells
por: Basoli, Valentina, et al.
Publicado: (2021)

Shear and Dynamic Compression Modulates the Inflammatory Phenotype of Human Monocytes in vitro
por: Fahy, Niamh, et al.
Publicado: (2019)

A Hyaluronan and Platelet-Rich Plasma Hydrogel for Mesenchymal Stem Cell Delivery in the Intervertebral Disc: An Organ Culture Study
por: Russo, Fabrizio, et al.
Publicado: (2021)

Anti-Inflammatory and Chondroprotective Effects of Vanillic Acid and Epimedin C in Human Osteoarthritic Chondrocytes
por: Ziadlou, Reihane, et al.
Publicado: (2020)

An impaired healing model of osteochondral defect in papain-induced arthritis
por: Meng, Xiangbo, et al.
Publicado: (2020)

The influence of intervertebral disc overloading on nociceptor calcium flickering
por: Gewiess, Jan, et al.
Publicado: (2023)

Isolation and Characterisation of a Recombinant Antibody Fragment That Binds NCAM1-Expressing Intervertebral Disc Cells
por: Cunningham, Claire, et al.
Publicado: (2013)

Mechanical Stress Inhibits Early Stages of Endogenous Cell Migration: A Pilot Study in an Ex Vivo Osteochondral Model
por: Vainieri, Maria L., et al.
Publicado: (2020)

One strike loading organ culture model to investigate the post-traumatic disc degenerative condition
por: Zhou, Zhiyu, et al.
Publicado: (2020)

Quality control methods in musculoskeletal tissue engineering: from imaging to biosensors
por: Zuncheddu, Daniele, et al.
Publicado: (2021)

Author Correction: Quality control methods in musculoskeletal tissue engineering: from imaging to biosensors
por: Zuncheddu, Daniele, et al.
Publicado: (2021)

BMP2 and TGF-β Cooperate Differently during Synovial-Derived Stem-Cell Chondrogenesis in a Dexamethasone-Dependent Manner
por: Kovermann, Nikolas J., et al.
Publicado: (2019)

Predicting and Promoting Human Bone Marrow MSC Chondrogenesis by Way of TGFβ Receptor Profiles: Toward Personalized Medicine
por: Rothweiler, René, et al.
Publicado: (2020)

Dexamethasone Induces Changes in Osteogenic Differentiation of Human Mesenchymal Stromal Cells via SOX9 and PPARG, but Not RUNX2
por: Della Bella, Elena, et al.
Publicado: (2021)

Intervertebral disc response to stem cell treatment is conditioned by disc state and cell carrier: An ex vivo study
por: Peroglio, Marianna, et al.
Publicado: (2017)

Transcriptional profiling of intervertebral disc in a post‐traumatic early degeneration organ culture model
por: Cui, Shangbin, et al.
Publicado: (2021)

Raman Spectroscopy in Skeletal Tissue Disorders and Tissue Engineering: Present and Prospective
por: Fosca, Marco, et al.
Publicado: (2022)

Monitoring live human mesenchymal stromal cell differentiation and subsequent selection using fluorescent RNA-based probes
por: Li, Bojun, et al.
Publicado: (2016)

Corrigendum: Monitoring live human mesenchymal stromal cell differentiation and subsequent selection using fluorescent RNA-based probes
por: Li, Bojun, et al.
Publicado: (2016)

Animal Models of Osteochondral Defect for Testing Biomaterials
por: Meng, Xiangbo, et al.
Publicado: (2020)

In Vitro Model to Investigate Communication between Dorsal Root Ganglion and Spinal Cord Glia
por: Ma, Junxuan, et al.
Publicado: (2021)

Polymeric Nanoparticles for Drug Delivery in Osteoarthritis
por: Pontes, Adriano P., et al.
Publicado: (2022)

The effects of 3D culture on the expansion and maintenance of nucleus pulposus progenitor cell multipotency
por: Guerrero, Julien, et al.
Publicado: (2020)

Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc
por: Collin, Estelle C, et al.
Publicado: (2017)

Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions
por: Kamali, Amir, et al.
Publicado: (2021)

Homing of vertebral‐delivered mesenchymal stromal cells for degenerative intervertebral discs repair – an in vivo proof‐of‐concept study
por: Schol, Jordy, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nkmt8ea0bo1k1suvabfk8cjb1l